Scientist l, Biopharmaceutics

Job Overview

The Molecular Profiling and Drug Delivery (MPDD) function within Abb Vie’s Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. MPDD scientists utilize state‑of‑the‑art automation and computational tools, expertise in biopharmaceutics, drug delivery, and solid‑state chemistry to collaborate on candidates with higher probability of success and advise on clinical formulation strategy.

Scientists work from candidate selection through clinical proof of concept and product launch, identifying the commercial solid form of the active pharmaceutical ingredient (API), establishing structure‑property‑performance correlations, and transitioning processes to commercial manufacturing sites while ensuring successful regulatory submissions.

• Design, execute, troubleshoot, and interpret experiments related to biopharmaceutics properties of small molecules and peptides (solubility, dissolution, permeability, stability, aggregation, precipitation, and formulation performance).
• Generate high‑quality data and maintain accurate, timely, and complete documentation of experimental procedures, results, and conclusions.
• Analyze and summarize data using appropriate scientific methods and communicate findings to project teams and functional stakeholders.
• Contribute to the assessment of candidate molecules and formulations by identifying key risks, opportunities, and data‑driven recommendations.
• Support development, optimization, and continuous improvement of experimental methods, workflows, and scientific capabilities.
• Maintain awareness of external scientific advances and incorporate relevant knowledge into project work where appropriate.
• Contribute to a collaborative, inclusive, and scientifically rigorous team environment.

• Bachelor’s Degree or equivalent with typically 5 years of experience, or master’s degree or equivalent with typically 2 years of experience in pharmaceutical or related industry; preferred backgrounds include Pharmaceutical Sciences, Engineering, Chemistry, Materials Science.
• Fundamental understanding of biopharmaceutics in relation to drug absorption across routes of administration (solubility, biorelevant dissolution testing, permeability, ex vivo permeability assessment, peptide aggregation).
• Hands‑on laboratory experience in in vitro assays and standard analytical techniques for physicochemical and biopharmaceutical property assessment (chromatography, DSF, rat intestinal perfusion, Ussing chambers, Franz diffusion cells, dissolution, X‑ray diffraction, thermal analysis, microscopy, biophysical characterization).
• Knowledge of preclinical and clinical formulation development principles for chemically synthesized molecules across routes of administration.
• Ability to analyze data and draw scientifically sound conclusions.
• Strong communication skills, ability to influence others without authority and drive technical excellence.
• Excellent self‑management, organizational skills, and attention to detail.

• USD 75,000 – USD 142,500 yearly (level and compensation commensurate with experience).

Abb Vie offers a comprehensive benefits package including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) to eligible employees. The role is eligible to participate in short‑term incentive programs.

Abb Vie is an equal‑opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer / Veterans / Disabled.