Senior Principal Research Scientist​/Principal Research Scientist II

About Abb Vie

Abb Vie is a global, research-based biopharmaceutical company that focuses on developing advanced therapies for complex diseases.

Senior Principal Research Scientist – Process Chemistry (Drug Conjugates, Peptides, and Small Molecules)

• Lead the setting and implementation of the Process Chemistry strategy for projects across therapeutic modalities.
• Lead project teams in process development and characterization across modalities, including translation of laboratory processes to scalable processes.
• Mentor staff in troubleshooting strategic and experimental issues and share knowledge with peers and senior leadership.
• Author and review regulatory documents, laboratory data, technical memos and reports.
• Collaborate with organic chemists, analytical chemists, engineers, drug product development scientists, asset strategy leadership, and program management.
• Identify and nurture ideas for continuous improvement activities and initiatives within Synthetic Molecules CMC R&D.
• Set project strategies, define responsibilities and timelines, develop control strategies, and provide leadership in a matrixed team setting.
• Develop robust processes for cGMP manufacturing.

• Minimum 18 years (BS), 16 years (MS), or 10 years (PhD) of experience in organic chemistry or related field; position can be at Senior Principal Research Scientist or Principal Research Scientist II level based on experience.
• Experience managing and developing scientific leaders and teams in CMC.
• Preferred experience with siRNA, antibody drug- and oligonucleotide-conjugates (AOCs), and high-potent compounds.
• Proven scientific leadership with strong interpersonal and communication skills for facilitating collaborations.
• Strong understanding of modern organic chemistry, mechanistic theory, control strategy development (including mutagenic impurity and nitrosamine controls), and regulatory starting material strategies.
• Understanding of global regulatory expectations and experience authoring development reports and regulatory filings.

• Compensation range provided is a possible base pay range; actual pay may vary based on location and other factors.
• Benefits include paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) for eligible employees.
• Eligible for long‑term incentive programs.
• Travel: 5% of the time.

Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8‑hour day).

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.

For more information on Equal Employment Opportunity, visit