Principal Research Scientist , Process Chemistry; Biocatalysis

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people s lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us  Follow @abbvie onLinked

In,Facebook,Instagram,Xand You Tube .

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people s lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us  Follow @abbvie onLinked

In,Facebook,Instagram,Xand You Tube .

The Process Chemistrygroup is responsible for inventing and executing the chemical processesforpreparing active pharmaceuticalingredients(API) to enable toxicology studies, clinical trials, and drug product development for Abb Vies pre-clinical and clinical candidates. We create valuable intellectual property through composition of matter, chemical processes, and technology,resulting in the development of safe and cost-effective commercial manufacturing processes. Abb Vie is seeking a highly skilled and innovative Principal Research Scientist Itocontribute tochemical process research and development of small molecules, peptides, antibody-drug conjugates, and other modalitiesviaexpertisein biocatalysis.

The selected candidate will contribute tothe development of biocatalytic processes for the scalable synthesis of active pharmaceutical ingredients (APIs),enzyme discovery,directed evolution campaigns,and application ofAI/MLtoolsfor the discovery and optimization of enzyme-catalyzed reactions.

Deep expertise inbiocatalysis,astrong foundation in synthetic organic chemistry, and the technical versatility to integrate modern computational and high-throughput experimentation tools into process development is required for this role.

• Contribute to thesetting and implementation of strategies for solvingcomplexsyntheticproblems in process development,via implementation ofbiocatalytic methods.
• Contribute to the identification and design of enzymes, application ofrecombinant DNA techniques, heterologous protein expression, and directed evolution methodologies to engineer biocatalysts with improved activity, selectivity, and stability in support of novel or improved synthetic transformations for API process development.
• Leverage AI/ML tools, bioinformatics platforms, and high-throughput experimentation (HTE) to accelerate enzyme screening, optimization, and process development cycles.
• Participate in and/or lead project teams associated with process development and characterization forsmall molecules,peptides, antibody-drug conjugates,and other modalities.
• Connect unrelated concepts to generate new ideasand always be on the lookout for the next big win.
• Author and review technical reports, regulatory documents, patents, and scientific publications,present findings at internal and external scientific forums.
• Understand and adhere to corporate standards regarding
  
  GxPcompliance, code of conduct, safety, and appropriate handling of materials.

• Bachelors, Masters, or PhD Degree inorganicchemistry with typically 14+ (BS), 12+ (MS) or6+ (PhD) years of experience.
• Expertise in synthetic organic chemistry with demonstrated hands-on experience inbiocatalysis, including enzyme screening, characterization, and application to synthetic transformations.
• Proficiency inrecombinant DNA techniquesand protein expression for enzyme production and engineering.
• Experience with high-throughput experimentation (HTE) platforms and data analysis workflows for rapid enzyme identification and reaction optimization.
• Demonstrated ability to employ AI/MLanddata science approaches to solve complexchemical synthesis problems.
• Demonstrated ability ininnovating new chemical and automation technologies.
• Proven scientific leadership; strong interpersonal and communication skills for facilitating collaborations.
• Experience insyntheticmoleculeprocess development.

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.
  
  Individual compensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/vision insurance and 401(k) to…