Associate Scientist II​/Scientist – Chemical Biology & Mass Spectrometry Technologies

Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

This position requires a BSc/ MSclevel scientist tomaximizetheimpact andproductivityofthe Chemical Biology and Mass Spectrometryand Technologies(CB&MST) teamforgenerationofdata todrivepipeline decisions.

This scientist will work collaboratively with team memberstotransition routine,low throughput sample preparationproceduresfortarget validation,targetengagement, and off-target profilinginto high precision / high throughputprocedureswith a focus in proteomics preparation methodologies and plate-based proteomics sample prep. Thesuccessfulcandidate will collaborate with teammates tooptimizeandperformautomatedsamplepreparationmethodologies and conduct mass spectrometry-based proteomicsexperimentstoenablethis transformation.

Work with team members to develop,validate,andimplementautomatedsample preparationworkflows for CB&MST activities, with an emphasis on plate-basedproteomics sample preparationusing cell lines, tissues and other biological matrices.

• Develop methods to automate chemical biology sample prep usingmagnetic bead-based enrichments andliquid handling.

• Collaborate with team members to establish, document, and maintain Standard Operating Procedures for routine workflows.

• Operate, monitor, and assist with the maintenance and troubleshooting of LC-MS instrumentation and associated laboratory equipment.

• Assist with data processing, quality assessment,and data interpretation.

• Interface andcollaboratewith colleague sand project teams in therapeutic areas to determine appropriatesamples and amounts required for studies.

• Bachelors or Masters in chemistry, biochemistry,chemical biology or related field with typically 3-5+ (BS), or 0-2+ (MS) years of experience.

• Hands-on bench skills for preparing samples for mass spectrometry, with a focus in proteomics sample preparationfrom cell lines and tissues.

• Ability to generate proteomics samples in 96-well platesandrunsamples on LC-MS instrumentation.

• Ability to workproficientlywithlaboratoryequipmenttypically found inachemical biology, biochemistry, or molecular biologylaboratory.

• Demonstrated ability totroubleshootand diagnose problems withcommonlaboratoryequipment.

• ExperienceutilizingLC/MSforproteomicsincludingcurrent models of Thermo and Bruker mass spectrometers.

• Experience with automation such as the Agilent Bravo, Thermofisher King Fisher,and Opentrons Flex.

• Ability to conductdifferent types of proteomics experiments including whole proteomics, phosphoproteomicsimmunoprecipitationproteomics,and targeted MS,etc.

• Experience in basic biochemistryand molecular biology techniquesincludingplate-basedassays,SDS-PAGE, western blotting,andmammaliantissue cultureis desired.

• Ability to conductbead- and probe-basedchemical biologyexperimentsthat utilize proteomics as a readout.

• Ability to effectively use AI to increase personal and team productivity.

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.

• Learns fast, grasps the 'essence' and can change the course quickly where indicated.

• Raises the bar and is never satisfied with the status quo.

• Creates a learning environment, open to suggestions and experimentation for improvement.

• Embraces the ideas of others, nurtures, and manages innovation to reality.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.
  
  Individual compensation paid within this range will depend on many factors including geographic location,andwemay ultimately pay more or less than the posted range. This range may be modified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note:

No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.

Theamountandavailabilityof anybonus,commission, incentive, benefits, or anyother form of compensation and benefits that are allocable to a particular employee remains in the Company'ssoleandabsolutediscretion unless and until paid andmay…