Scientist II, In Vivo Pharmacology

Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us  Follow @abbvie onLinked

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Our expanding In Vivo Tumor Biology group in Lake County, IL is hiring a motivated tumor biologist dedicated to discovering and developing innovative small-molecule and biologic therapeutics. The position will focus on tumor-targeting biologics including ADCs and T-cell engager (TCE) therapeutics in both immunocompromised and humanized mouse models. Our scientists collaborate with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&D pipeline.

The position is within a dynamic, collaborative research team passionate about advancing novel science and improving patients' lives

The successful candidate will have expertise in designing and executing studies using tumor models in both immunocompromised and immunocompetent mice. Excellent communication skills and a willingness to work with a multidisciplinary team of researchers are essential.

Strong candidates have experience in ADC and TCE therapeutics and familiarity with humanized mouse studies.

Core Responsibilities:

• Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic)
• Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies.
• Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq
• Identify, validate and utilize humanized mouse models to support Abbvie pipeline assets.
• Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals.
• Perform routine and complex tasks competently and independently. May innovate new experimental protocols/techniques.
• Appetite for developing novel in vivo approaches and models to address complex biological questions.

• BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.

  Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.

  Demonstrated ability to learn, understand and master new experimental techniques.

  Ability to multitask and work within timelines.

  Demonstrated scientific writing skills and strong verbal communication skills.

Key Leadership Competencies

• Builds strong relationships with peers and cross-functionally with partners outside the team to enable higher performance.
• Learns quickly and changes course when indicated.
• Raises the bar and is never satisfied with the status quo.
• Embraces others' ideas, nurtures innovation and brings it to reality.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.
  
  Individual compensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

• We…