Principal Research Scientist , Process Chemistry; Biocatalysis

Principal Research Scientist I, Process Chemistry (Biocatalysis)

• Full-time
• Salary Min: 124500
• Salary Max: 236500
• Workday Global Grade: 19
• Compensation: USD 124500 - USD 236500 - yearly

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us  .

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The Process Chemistrygroup is responsible for inventing and executing the chemical processesforpreparing active pharmaceuticalingredients(API) to enable toxicology studies, clinical trials, and drug product development for Abb Vie's pre-clinical and clinical candidates. We create valuable intellectual property through composition of matter, chemical processes, and technology,resulting in the development of safe and cost-effective commercial manufacturing processes.

Abb Vie is seeking a highly skilled and innovative Principal Research Scientist Itocontribute to chemical process research and development of small molecules, peptides, antibody-drug conjugates, and other modalitiesviaexpertisein biocatalysis.

The selected candidate will contribute tothe development of biocatalytic processes for the scalable synthesis of active pharmaceutical ingredients (APIs),enzyme discovery,directed evolution campaigns,and application ofAI/MLtoolsfor the discovery and optimization of enzyme-catalyzed reactions.

Deep expertise inbiocatalysis,astrong foundation insynthetic organic chemistry, and the technical versatility to integrate modern computational and high-throughput experimentation tools into process development is required for this role.

Responsibilities:

Contribute to the setting and implementation of strategies for solvingcomplexsyntheticproblems in process development,via implementation ofbiocatalytic methods.

Contribute to the identification and design of enzymes, application ofrecombinant DNA techniques, heterologous protein expression, and directed evolution methodologies to engineer biocatalysts with improved activity, selectivity, and stability in support of novel or improved synthetic transformations for API process development.

Leverage AI/ML tools, bioinformatics platforms, and high-throughput experimentation (HTE) to accelerate enzyme screening, optimization, and process development cycles.

Participate in and/or lead project teams associated with process development and characterization forsmall molecules,peptides, antibody-drug conjugates,and other modalities.

Connect unrelated concepts to generate new ideasand always be on the lookout for the next big win.

Author and review technical reports, regulatory documents, patents, and scientific publications,present findings at internal and external scientific forums.

Understand and adhere to corporate standards regarding

GxPcompliance, code of conduct, safety, and appropriate handling of materials.

Bachelor’s, Master’s, or PhD Degree inorganic chemistry with typically 14+ (BS), 12+ (MS) or6+ (PhD) years of experience.

Expertise insynthetic organic chemistry with demonstrated hands-on experience inbiocatalysis, including enzyme screening, characterization, and application to synthetic transformations.

Proficiency inrecombinant DNA techniques and protein expression for enzyme production and engineering.

Experience with high-throughput experimentation (HTE) platforms and data analysis workflows for rapid enzyme identification and reaction optimization.

Demonstrated ability to employ AI/MLanddata…