Sr. Scientist, Virus Construction

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The Senior Scientist, Virus Construction, plays a key role in managing the design, development and testing of novel HSV-derived oncolytic virus candidates. The Senior Scientist, Virus Construction will drive key projects and will use their knowledge and experience of molecular, cellular, computational or other technologies to introduce and develop new methods to further characterize oncolytic virus products.

The Senior Scientist, Virus Construction will additionally support translational research, biodistribution, toxicity, sequencing or other studies when required, including performing data analysis using statistical techniques, final data preparation, presentation, and reporting. The Senior Scientist, Virus Construction, may also act as line manager for other members of the Virus Construction team.

This position is based in our Milton Park location and typically has a 5-day on-site expectation.

Manage and execute the design and construction of new oncolytic virus candidates in accordance with regulatory guidelines and requirements.

Manage and execute the testing of novel oncolytic viruses using previously established and novel methods to confirm successful construction.

Drive introduction, evaluation and qualification of methods for virus characterization and oversee execution and transfer to other departments e.g. AD, PD, etc., where required.

Produce and assess critical materials required by other departments e.g. cell banks, virus controls and other biological materials.

Coordinate and execute the batch production and testing of non-GMP virus material for use in internal studies and external collaborations.

Contribute technical input to regulatory submissions and information requests e.g. BLA, IND, IMPDs.

Collaborate with other functions e.g. Translational Research to support external clinical and non-clinical studies e.g. efficacy, toxicology, biodistribution and shedding etc, where required, through provision of virus material, technical input and data analysis.

Drive the daily operation of the Virus Construction department, ensuring laboratories are maintained and operations are completed in accordance with company policies and procedures, e.g. Health and Safety, Biological Safety, equipment, consumables management etc.

Provide subject matter expert input relating to biological safety of existing and novel oncolytic viruses and GMOs and other safety-related activities.

Represent Virus Construction department in cross-functional projects with Analytical Development, Translational Research, Process Development, Quality Assurance, Regulatory Affairs and external partners.

Provide direct line management, mentorship or training for other members of the Virus Construction department if required.

Manage, author and review relevant technical reports, SOP’s, risk assessments and other documentation as required.

B.A or

B.Sc. degree in a relevant biological…