Senior Engineer II, Applied Technologies

** The Role
** Joining Moderna offers the unique opportunity to be part of a pioneering team that's revolutionizing medicine through mRNA technology, with a diverse pipeline of development programs across various diseases.

As an employee, you'll be part of a continually growing organization, working alongside exceptional colleagues and strategic partners worldwide, contributing to global health initiatives.

Moderna's commitment to advancing the technological frontier of mRNA medicines ensures a challenging and rewarding career experience, with the potential to make a significant impact on patients' lives worldwide.

This high-impact individual contributor role will lead the strategy and deployment of Process Analytical Technology (PAT) across Moderna’s mRNA drug substance and drug product platforms. You will architect and implement cutting-edge inline, online, and at-line analytical tools that unlock real-time monitoring and data-driven control from early-stage development through GMP manufacturing. Working across functional boundaries, you will build the digital and analytical backbone of next-generation bioprocessing.

This is a unique opportunity to operate at the intersection of automation, advanced analytics, and mRNA science — and to shape how Moderna integrates Generative AI tools and intelligent control systems into its manufacturing future.
** Here’s What You’ll Do
**** Your key responsibilities will be:
*** Lead the end-to-end PAT and control strategy, ensuring cross-platform consistency and alignment with Moderna’s digital and automation roadmaps.
* Design, deploy, and maintain a diverse suite of spectroscopic, chromatographic, and sensor technologies (e.g., Raman, FTIR, UPLC, rapid sterility, pH/DO micro sensors).
* Develop chemo metric models and real-time dashboards linking process parameters with critical quality attributes.
* Serve as a technical lead on integration of PAT tools into Moderna’s digital ecosystem — including data lakes, electronic batch records (e ), and advanced process control layers.
* Author and lead technology transfer packages to internal GMP sites and external partners, ensuring seamless comparability and calibration approaches.
** Your responsibilities will also include:
*** Collaborate closely with analytical development, MS&T, process automation, digital, engineering, quality, and regulatory teams to ensure PAT solutions are seamlessly manufacturable and inspection-ready.
* Drive continuous improvement initiatives that reduce cycle times, enhance right-first-time metrics, and improve overall process robustness.
* Mentor staff and champion a scientific culture of curiosity, innovation, and excellence.
* Translate complex analytical and regulatory requirements into integrated solutions aligned with Moderna’s next-gen manufacturing platforms.
* Travel up to 10%, supporting deployment at domestic and international manufacturing sites.
** The key Moderna Mindsets you’ll need to succeed in the role:**
* ** We digitize everywhere possible using the power of code to maximize our impact on patients.
** In this role, you'll be instrumental in embedding real-time PAT data into Moderna’s digital infrastructure, laying the groundwork for automated insights and AI-driven decisions across the manufacturing network.
* ** We push past possible to be the best version of Moderna.
** You'll be expected to pioneer forward-thinking PAT strategies, challenge conventional approaches, and set new benchmarks for what real-time analytics can deliver in a fully digital biotech environment.
** Here’s What You’ll Need (Basic Qualifications)
*** Ph.D. in Chemical/Biomedical Engineering, Analytical Chemistry, or related discipline with 2+years, OR M.S. with 8+years, OR B.S. with 10+years of relevant industrial experience.
* Hands-‑on experience developing and implementing PAT tools in biopharmaceutical or advanced ‑therapy manufacturing environments, including sensor specification, installation, and data ‑modelling, and technology transfer.
* Proficient in multivariate data analysis/chemometrics tools (SIMCA, Unscrambler, Python, R) and integration with process automation systems, manufacturing data…