Sr. Research Associate, Analytical Technical Operations

Moderna is strengthening its presence in Norwood, Massachusetts, a cornerstone of our manufacturing and operational excellence. As a Senior Research Associate within Analytical Technical Operations, you will execute critical bioassay testing to support development, characterization, release, and stability programs across Moderna’s mRNA pipeline.

• Perform routine cell‑based ELISA assays to evaluate in vitro relative protein expression (IVRPE) across development, characterization, release, and stability samples.
• Culture and maintain mammalian cell lines using aseptic technique, ensuring optimal cell health, confluency, and viability.
• Prepare assay plates, execute transfections, and manage multi‑day workflows with precision and consistency.
• Conduct serial dilutions, reagent preparation, sample handling, and plate‑based assay execution in alignment with established protocols.
• Monitor assay performance and respond to routine experimental issues with limited oversight, applying strong troubleshooting skills.
• Operate laboratory instrumentation including plate readers, plate washers, incubators, biosafety cabinets, and associated equipment.
• Acquire, review, and analyze experimental data using established tools, including curve‑fitting methodologies.
• Maintain accurate, organized, and inspection‑ready records within laboratory systems and notebooks.
• Provide day‑to‑day technical guidance to Research Associates on assay execution, laboratory best practices, and troubleshooting fundamentals.
• Troubleshoot experimental challenges, support investigations, and proactively identify opportunities to enhance assay robustness, efficiency, and scalability.
• Lead or contribute to optimization of assay protocols and workflows to improve data quality, throughput, and readiness for automation.
• Support method transfers and the implementation of automated workflows, leveraging digital tools and emerging generative AI technologies to enhance analytical insights.
• Perform additional responsibilities as needed to support evolving Technical Development priorities.

“We behave like owners.” “We obsess over learning.”

Basic Qualifications

• MS or Bachelor’s degree in Biology, Biochemistry, Cell Biology, or related field with 2+ years of relevant laboratory experience.
• Hands‑on laboratory experience in cell culture and/or bioassays.
• Basic understanding of ELISA or immunoassays.
• Experience with mammalian cell culture techniques.
• Familiarity with aseptic technique.
• Strong organizational and time‑management skills.

Preferred Qualifications

• Master’s degree with 2–3 years of experience, or BS/BA with 3–5 years of experience in a relevant field.
• Hands‑on experience with cell‑based ELISA, IVRPE, or potency assays.
• Strong working knowledge of ELISA, immunoassays, or other plate‑based assays.
• Experience with mammalian cell culture (adherent and suspension) and aseptic technique.
• Experience with plate‑based assays, multichannel pipetting, and multi‑day assay workflows.
• Familiarity with plate reader software, electronic laboratory documentation, and routine data analysis.
• Experience with method troubleshooting, assay transfer support, or implementation of improved workflows.
• Demonstrated ability to troubleshoot experiments and improve assay performance.
• Experience training or mentoring junior staff.
• Strong attention to detail and ability to follow and improve detailed procedures.
• Ability to work collaboratively in a team environment.
• Adaptability in a fast‑paced laboratory setting.
• Strong organizational and time‑management skills.

Site‑based, requiring presence at Moderna’s Norwood, Massachusetts location full‑time. This position is not eligible for remote work.

Competitive salary range: $74,000.00 – $. Additional benefits include healthcare, voluntary benefit programs, fitness & mindfulness resources, family planning benefits, paid time off, savings & investments, and location‑specific perks.

Moderna is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to race, color, sex, gender identity or expression, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation, marital status, or any other protected characteristic. Moderna is a smoke‑free, alcohol‑free, and drug‑free work environment.