Scientist , Separations and Biophysical Characterization

DESCRIPTION

Who We Are

Bio Marin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.

Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.

Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best – people with the right technical expertise and a relentless drive to solve real problems – and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we’ve produced a diverse pipeline of commercial, clinical and preclinical candidates that have well‑understood biology and provide an opportunity to be first‑to‑market or offer a substantial benefit over existing therapeutic options.

About Technical Operations

Bio Marin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain Bio Marin’s cutting‑edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients.

The Analytical Sciences group, part of the Technical Development & Services department at Bio Marin Pharmaceutical Inc., is seeking a Scientist 2 for the Separations and Biophysics Assays team. This position will focus on biophysical method development and the characterization of protein‑based therapeutics - enzymes, conjugated proteins, peptides, emphasizing biochemical and biophysical characterization of these molecules and their degradation products to support CMC product development across early, late‑stage, and commercial assets.

This includes structure function relationship, solubility profiles, thermodynamics/kinetics and interactions. The ideal candidate will demonstrate strong motivation, critical thinking abilities, effective communication skills, and experience working successfully in multidisciplinary, fast‑paced environments.

The candidate will be responsible for developing methods utilizing a range of biophysical techniques, including AUC, CD, DSC, DSF, DLS, ITC, SEC‑FFF/MALS and other relevant technologies. Responsibilities also include managing sample testing, compiling test results, and effectively summarizing findings. The individual should demonstrate exceptional organizational, analytical, and communication abilities, and exhibit initiative and efficiency while collaborating in a dynamic, team‑oriented environment.

The ideal candidate will have extensive experience and strong expertise in characterizing proteins, peptides, and other modalities using diverse biophysical and analytical methods. Effective communication with cross‑functional teams, proactive problem‑solving, and collaboration in multidisciplinary settings are essential. Solid knowledge of protein chemistry and biochemistry is required, along with hands‑on experience in CMC development of recombinant biologics, peptide and small molecule therapies, and familiarity with ICH guidelines and regulatory submissions.

• Manage the development, optimization and implementation of biophysical characterization activities within Analytical Sciences for various protein‑based therapeutics and other modalities.
• Design and conduct studies independently, including but not limited to assess protein structure, structure‑function relationship, protein‑excipient compatibility, solubility, and binding kinetics and affinities.
• Use biophysical methods (AUC, CD, DSC, DSF, DLS, ITC, SEC‑FFF/MALS) to analyze stability and solution properties for various therapeutics.
• Develop and qualify biophysical methods for products from early (pre‑clinical) to commercial…