Senior Manager, Contracts

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical‑stage company currently focused on post‑bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

We are seeking an experienced Contracts Manager to help refine and scale our contracting operations as we prepare for a potential drug launch. This role will own the full contract lifecycle process—from intake and template selection through negotiation support, execution, and post‑execution management. It is a highly visible, customer‑service oriented role that will serve as the internal subject‑matter expert and trainer for Amylyx’s contract lifecycle management system (CLMS).

The ideal candidate will have a strong background in contract management within the life sciences, biotech, or pharmaceutical industry and thrive in a fast‑moving, evolving environment.

• Optimize and implement contracting processes and best practices
  , ensuring efficient workflows, compliance, and continuity across teams.
• Manage end‑to‑end contract lifecycle for a broad set of contracts, e.g. services, confidentiality, research collaborations, and other commercial or operational contracts.
• Maintain the contract management system and repository
  , including metadata accuracy, key date tracking, renewal management, obligation monitoring, tags, parties and reporting.
• Partner closely with internal stakeholders (Legal, Compliance, Finance, Procurement, Clinical, Commercial, and other business partners) to ensure contract terms align with business and compliance needs.
• Develop, update, and maintain contract templates and playbooks in partnership with Legal advisors.
• Develop and maintain CLMS training materials and provide new hire and refresher training sessions as well as ad‑hoc support.
• Establish and track contracting KPIs
  , dashboards, and metrics to provide visibility into system performance and contracting volume.
• Partner with the IT Administrator to drive continuous contracting process improvements
  , including identifying opportunities to streamline workflows through automation and the use of Artificial Intelligence tools.

• Bachelor’s degree required;
  JD or Paralegal Certification preferred.
• 3–5 years of experience in contract management and with CLM system(s).
• Strong ability to prioritize, independently manage workload, and meet deadlines in a dynamic environment.
• Exceptional written, verbal, and interpersonal communication skills with a focus on customer service and excellent attention to detail.
• Proven ability to work with cross‑functional teams and build strong internal relationships.
• Aligned with a patient‑focused mission and able to uphold the highest standards of integrity.

• Experience with Link Squares contract lifecycle management system.
• Demonstrated experience applying AI tools to contract review or process optimization.
• Industry experience in biotech, pharma, or life sciences
  .

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company‑related events as necessary and requested.
• You must have access to a work…