Technical Project Manager – Radiopharmaceutical Program

Technical Project Manager – Radiopharmaceutical Program

Orchestra Life Sciences is a technical consultancy delivering deep expertise in nuclear medicine development, specializing in Radioligand Therapies (RLTs) and Targeted Alpha Therapies that are transforming cancer treatment. We provide end-to-end capital project solutions that take specialized facilities from feasibility studies through cGMP qualification, with a proven track record of optimizing regulatory compliance, costs, and timelines. Our team of subject matter experts brings more than 100 years of combined experience in novel therapies, working in concert with clients across nuclear medicine, radiation oncology, cell and gene therapies, regenerative medicines, and biotechnology to accelerate life-saving treatments to market.

We are seeking a Technical Project Manager to join our growing Radiopharmaceutical Program team, managing complex, multi-disciplinary projects at the forefront of nuclear medicine. This role offers a unique opportunity to drive delivery excellence across a portfolio of high-impact capital equipment projects—including hot cells, cyclotrons, and large-scale process systems—as well as process scale-up and commercialization initiatives. You will serve as the central coordinator and accountable owner of project execution, working closely with process engineers, mechanical engineers, automation specialists, quality teams, and clients to keep programs on scope, schedule, and budget.

Your work will directly enable life-saving cancer therapies to reach patients.

This is a hybrid position offering flexibility to work from home, our Madison office, and client project sites nationwide. Project phases require varying levels of face‑to‑face collaboration for effective delivery. Travel expectations typically range from 25–50%. Travel requirements may increase during critical project phases such as equipment procurement, Factory Acceptance Testing (FAT), commissioning activities, and startup operations. Travel is scheduled during business days to support project delivery;

extended travel over weekends to enable consecutive weeks onsite is not typical practice.

• Own end-to-end project delivery for capital equipment and process projects, including scope definition, integrated scheduling, resource planning, risk management, and budget tracking
• Develop and maintain project plans, work breakdown structures (WBS), and critical path schedules for multi-disciplinary teams across engineering, procurement, construction, and qualification phases
• Drive accountability across internal team members and external vendors, ensuring milestone commitments are met and issues are escalated with solutions

• Manage projects for large capital equipment including hot cells, cyclotrons, isolators, containment systems, and process skids from concept through commissioning and handoff
• Coordinate procurement, vendor management, and logistics for specialized radiopharmaceutical equipment, interfacing with hot cell suppliers (e.g., Comecer, Von Gahlen, PBL) and other OEM partners
• Support Factory Acceptance Testing (FAT), Site Acceptance Testing (SAT), and equipment qualification (IQ/OQ/PQ) activities, ensuring execution against approved protocols and documentation requirements
• Interface with facility design teams, architects, construction partners, and client operations teams to ensure equipment and process requirements are aligned with building systems and site readiness

• Lead project management for radiopharmaceutical process scale‑up initiatives, from R&D through pilot and commercial manufacturing, coordinating cross-functional work streams across process engineering, quality, and regulatory teams
• Track and report on critical process parameters, technology transfer milestones, and regulatory submission timelines, ensuring dependencies are visible and risks are proactively managed
• Partner with process engineers to develop project-level plans for process validation, equipment qualification, and operational readiness…