Director​/VP R&D Portfolio Finance

Job Title:

Director/VP R&D Portfolio Finance

Are you a strategic finance leader with a passion for innovative pharmaceutical and biotech development? We are seeking a dynamic Director or Vice President of R&D Portfolio Finance to drive financial strategy, portfolio management, and investment decisions for a cutting-edge organization committed to advancing life sciences. This pivotal role offers the opportunity to collaborate with senior leadership, shape company-wide R&D priorities, and implement scalable processes that maximize pipeline value.

If you thrive in a fast-paced environment and have a proven track record in managing complex R&D portfolios, this is your chance to make a significant impact in the future of healthcare.

• Demonstrated experience leading financial components of pharmaceutical or biotech R&D programs and portfolio management
• Expertise in portfolio prioritization, governance, scenario development, resource allocation, and investment evaluation
• Ability to challenge clinical, operational, regulatory, CMC, and commercial assumptions with sound financial analysis
• Strong track record in developing portfolio decision frameworks, including probability-weighted scenarios and risk-adjusted economics
• Executive presence and proven ability to facilitate difficult investment and prioritization discussions with senior leadership
• Experience implementing scalable portfolio processes and governance models
• Proficiency with financial modeling, scenario analysis, and portfolio reporting tools
• Partnering experience with Commercial or Business Development teams is highly desired
• Systems familiarity:
  Adaptive Insights, Smartsheet, Excel; knowledge of other planning or portfolio tools is a plus

• Experience with clinical trial forecasting, milestone-based funding, and scenario analysis
• Knowledge of regulatory and commercialization pathways
• Ability to influence decision-making at the executive level
• Experience in healthcare strategy, competitive analysis, and asset valuation

• Bachelor’s degree in Finance, Business, or related field (Master’s or MBA preferred)
• 10+ years of relevant experience in biotech/pharma R&D finance or portfolio management, including leadership roles
• Prior experience working in fast-growing biotech or pharmaceutical companies, supporting R&D investment decisions

• Location:
  
  Hybrid (preferably 2 days/week onsite in South SF, with flexibility for remote work)
• Travel:
  Minimal; as required for stakeholder engagement
• Start Date:
  
  ASAP
• This position reports to the CFO and will work closely with senior leadership, portfolio teams, and finance partners