Research Investigator

A cover letter and the contact information for three (3) references are required for consideration for this position and should be attached to your CV. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

The Department of Pharmacology at the University of Michigan Medical School is recruiting a Research Investigator to join the Sebag laboratory. The Sebag laboratory focuses on identifying new pathways involved in the control of energy and glucose homeostasis and discovering novel targets for the treatment of obesity and diabetes. The laboratory's main focus is understanding the role and mechanism of G protein-coupled receptor (GPCR) regulation by the Melanocortin Receptor Accessory Protein 2 (MRAP2).

MRAP2 is a critical protein for the maintenance of proper energy and glucose balance. Deletion of MRAP2 causes obesity and insulin resistance, however, the mechanisms involved are poorly understood. The laboratory is also studying new regulators of insulin-stimulated glucose transporter 4 (GLUT4) translocation, using high throughput screening and structural biology.

The selected candidate's responsibilities will include but are not limited to conducting an independent research project and taking on general lab tasks, which involve the following: assisting in training and overseeing trainees; performing in vivo experiments, such as stereotaxic surgeries, behavioral assays, brain slice preparation, glucose tolerance tests (GTT), and insulin tolerance tests (ITT); using cell cultures and performing biochemical and pharmacology experiments in vitro, including cyclic adenosine mono phosphate (cAMP) assays and western blots;

designing, carrying out, interpreting, and analyzing experiments; presenting results at scientific meetings; writing and publishing results; and assisting the PI with grant applications as well as applying for independent funding.

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Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems.

In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

• Excellent medical, dental and vision coverage effective on your very first day
• 2:1 Match on retirement savings

• Ph.D. in Pharmacology, Medical Biology or related field
• Extensive experience performing glucose tolerance tests (GTT) and insulin tolerance tests (ITT)
• Experience performing stereotaxic surgeries and behavioral assays
• Experience performing cyclic adenosine mono phosphate (cAMP) assays

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes .

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

The University of Michigan is an equal employment opportunity employer.