Senior Medical Director, Clinical Development - Neuroscience

Overview

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

The company has a robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, and three investigational clinical-stage programs currently enrolling: ARV-102 for neurodegenerative disorders, ARV-393 for relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for solid tumors with KRAS G12D mutations. In 2025, the FDA accepted the NDA for vepdegestrant, an investigational, orally bioavailable PROTAC estrogen receptor degrader, for use as monotherapy in adults with ER+/HER2-, ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine therapy;
Arvinas and Pfizer announced plans to jointly select a third party for out-licensing and commercialization of vepdegestrant. In 2024, Arvinas entered into a global license agreement with Novartis for the development and commercialization of ARV-766 for prostate cancer, with the transaction closing in 2024.

#Team Arvinas is made up of passionate and curious employees whose diverse thoughts and perspectives are valued. Employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission—to improve the lives of patients with serious diseases by pioneering therapies created with our PROTAC protein degradation platform. Learn more about life at Arvinas and what employees have to say at

Arvinas is looking for an experienced Senior Medical Director with the passion and creativity to develop great medicines for neuromuscular and neurodegenerative diseases. The ideal candidate is a physician with global drug development program and global filing experience who is enthusiastic about applying their knowledge to patients around the globe who have no approved therapies for their disease. The individual will be a self-starter with excellent management and leadership capabilities who seeks to lead and be part of an innovative team that will drive drug development from start to finish.

Reporting into the Vice President of Clinical Research, the Senior Medical Director will be responsible for the strategy, development and execution of clinical research and development programs, including leadership of pivotal trials and filing activities. This position will serve as a key liaison between the company and clinical investigators, and will establish credible relationships with opinion leaders, regulatory officials and other key stakeholders and partners.

The successful candidate will be ready for a career-defining experience and have the passion to drive therapeutics for serious diseases to final approval. This role can be located at the New Haven, CT headquarters or with a hybrid or remote work arrangement within the U.S.

• Partner with discovery and biology leadership to provide clinical input and guidance for neuroscience strategy.
• Design trials for Phase I/II/III research targeting neurologic diseases, with expertise in CNS/Neurology and trial stewardship.
• Directly supervise and monitor trial conduct.
• Work with all functions and external partners to manage trial execution and investigators’ engagement.
• Collaborate on global regulatory plans and participate in regulatory meetings with regulatory affairs; identify opportunities for external collaboration.
• Monitor developments in the scientific literature and maintain external expert contacts to support understanding of candidate drug effects and strategic insights for study and program development.
• Develop effective relationships with external providers.
• Provide…