Scientist I​/II, Pre-Clinical

Role Summary

We are seeking a talented, dedicated, passionate and motivated individual with experience in the design and execution of pre‑clinical proof‑of‑concept in vitro and in vivo studies of genetic medicines to join our team as Scientist I/II. The ideal candidate will have a robust background in basic and translational research and be proficient in planning and executing in vitro and in vivo pre‑clinical efficacy studies.

They will also be capable of managing projects, fostering collaborations with Key Opinion Leaders (KOLs) and overseeing partnerships with vendors and academic partners for pre‑clinical studies. This is a highly collaborative role where the successful candidate will join a multi‑disciplinary team focused on developing the next generation of cardiac genetic medicines.

• Design and execute proof‑of‑concept genetic medicine studies in cell lines, primary cells, iPSC‑derived cells and animal models
• Design and oversee in vitro and in vivo pre‑clinical studies to evaluate the efficacy and safety of genetic medicine strategies with CROs and external partners
• Develop and execute assays for in vitro and in vivo phenotypic outcomes using next‑generation sequencing (NGS), PCR, qPCR, flow cytometry, Western blots and/or ELISA
• Analyze and interpret data and present to internal and external audiences
• Contribute to the scientific efforts and develop innovative solutions by maintaining a broad understanding of the field

• PhD degree (in life sciences or related discipline) and at least 2 years of industry or postdoc experience or MS degree with at least 4 years of relevant experience in industry or academia
• Extensive experience with mammalian cell culture including primary human cells is required, culturing of iPSCs and iPSC‑derived cardiomyocytes is a plus
• Technical experience in genomics and molecular and cellular biology (NGS, PCR, qPCR, flow cytometry, Western blots, ELISA)
• Familiarity with drug discovery for genetic medicines
• Ability to multi‑task and excel in a fast‑paced environment
• Excellent troubleshooting, written/verbal communication and project management skills
• Proficiency with applications used for scientific data analysis (e.g., Graph Pad, MS, JMP, etc)

Lexeo Therapeutics is a clinical‑stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.

Our work culture is a hybrid model with 2 days/week in the New York City office and 3 days working from home.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.