Executive Director, US Value & Access

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

The Executive Director, Value & Access serves as the senior U.S. enterprise leader accountable for defining and advancing U.S. payer access, reimbursement, and value strategy across Ionis’ commercial portfolio. This role shapes enterprise access strategy to ensure optimal patient access, sustainable coverage, and long-term value realization for Ionis therapies.

As a second-line leader, the Executive Director sets the strategic vision, operating model, and performance standards for the U.S. Value & Access function, leading Director-level leaders and building a high-performing, scalable organization. This individual will play a critical role in influencing enterprise decision-making by integrating payer insights into brand strategy, evidence planning, and lifecycle management.

This position operates with significant autonomy and executive visibility, translating complex payer dynamics into actionable business strategies that drive competitive advantage and sustainable growth.

• Own the development and execution of integrated U.S. payer strategies across the Ionis commercial portfolio.
• Establish long-range access vision, coverage objectives, and reimbursement strategies aligned with brand and corporate priorities.
• Shape and implement enterprise-level access frameworks that can scale across current and future launches.
• Identify, quantify, and proactively mitigate access risks and reimbursement barriers.
• Provide forward-looking analysis of payer landscape shifts, policy changes, and competitive access dynamics.
• Lead U.S. access readiness strategy from pre-launch planning through lifecycle optimization.
• Oversee development of payer-facing and field access materials.
• Ensure alignment of clinical and economic evidence generation with payer requirements in partnership with HEOR and Medical Affairs.
• Influence economic modeling, value frameworks, and budget impact strategies to support coverage negotiations.
• Oversee pull-through strategies to accelerate coverage adoption and minimize patient access friction.
• Lead and develop a high-performing U.S. Value & Access organization and drive team execution to achieve measurable access outcomes
• Establish clear strategic priorities and ensure alignment of resources against enterprise objectives.
• Build scalable capabilities to support portfolio expansion and future product launches.
• Foster a culture of collaboration, accountability, and continuous improvement.
• Partner closely with Brand,…