Senior Medical Director Clinical Development Neuroscience

Senior Medical Director Clinical Development Neuroscience

Remote, Hybrid, New Haven - CT

Arvinas is a clinical‑stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life‑threatening diseases through the discovery, development, and commercialization of therapies that degrade disease‑causing proteins. Arvinas uses its proprietary PROTAC® Discovery Engine platform to engineer proteolysis‑targeting chimeras, or PROTAC® targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease‑causing proteins.

Arvinas is currently progressing multiple investigational drugs through clinical development programs, including ARV‑102, targeting LRRK2 for neurodegenerative diseases; ARV‑806, targeting KRAS G12D for mutated cancers, including pancreatic, colorectal, and non‑small cell lung cancers; ARV‑393, targeting BCL6 for relapsed/refractory non‑Hodgkin Lymphoma; ARV‑027, targeting the polyglutamine‑expanded androgen receptor, or polyQ‑AR, in skeletal muscle; and vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2‑ breast cancer.

Arvinas is looking for an experienced Senior Medical Director with the passion and creativity to develop great medicines for neuromuscular and neurodegenerative diseases. The ideal candidate is a physician with experience in global drug development and filing, who is enthusiastic about applying their knowledge to improve the lives of patients with neurological diseases. This individual has excellent management and leadership capabilities and is motivated to participate in and lead an innovative drug development team.

Reporting to the Executive Medical Director of Clinical Research, Neuroscience, the Senior Medical Director will be primarily responsible for the development, oversight, and execution of clinical research and development programs, including pivotal trials and filing activities. This position will serve as a key liaison between company and clinical investigators and establish credible relationships with opinion leaders, regulatory officials and other key stakeholders and partners.

The successful candidate will be ready for a career defining experience and have the passion to drive several therapeutics for serious debilitating diseases to final approval.

This role can be located at our headquarters in New Haven, CT or work with a hybrid or remote work arrangement from a location within the U.S.

• Partner with discovery and biology leadership and provide clinical input and guidance to develop the neuroscience corporate strategy.
• Design Phase I/II/III research trials targeting neurologic diseases, requiring expertise and stewardship in the areas of CNS/Neurology.
• Monitor the safety of patients enrolled in clinical studies.
• Provide medical and scientific input in review of clinical data, patient medical safety data, and laboratory values, maintaining an ongoing assessment of the safety profile, and efficacy data, as appropriate.
• Work closely with all functions of the organization and external partners to manage trial execution and investigators’ engagement.
• Collaborate in developing global regulatory plans and play a key role in regulatory meetings in partnership with regulatory affairs.
• Identify, develop, and maintain relationships with external experts to better understand the candidate drug’s effects and gain strategic insights to strengthen the program.
• Provide clinical assessments of potential in‑licensing assets, identifying novel therapeutics opportunities as well as critical study design and execution challenges.
• Lead the interpretation and summary of clinical trial data, including the preparation of study reports, integrated summaries, and clinical portions of package inserts and other product labeling.
• Provide input on and review of various reports, applications, and publications.
• Ensure consistent practices with the highest ethical standards in compliance with internal SOPs, local regulations, and laws.

• Participate in the selection of…