Project Manager, THRIVE PERC Program

The Pediatric Epilepsies & Rare CNS (PERC) Gene Editing Platform is the Center for Therapeutic Genetics (CTG) project funded by ARPA-H’s THRIVE program. PERC aims to develop and clinically deploy platformized delivery of precision gene editors to treat children with developmental and epileptic encephalopathies (DEEs), including Alternating Hemiplegia of Childhood and Dravet syndrome. CTG at the Broad Institute serves as the coordinator hub for PERC, responsible for program leadership, regulatory strategy, centralized data management, IP stewardship, and other key administrative and operational tasks.

The program spans IND-enabling nonclinical studies, CMC development with CDMO partners, clinical trial execution, and regulatory strategy targeting first-in-human dosing in less than 2 years. The ARPA-H THRIVE PERC Project Manager will own end-to-end operational coordination across a complex, multi-institutional team that includes the Broad Institute, the Jackson Laboratory, Boston Children’s Hospital, Children’s Hospital of Colorado, various patient advocacy organizations, and several biotech and industry partners.

The PM will be responsible for ensuring program advancement on timeline against ARPA-H’s defined objectives, metrics, and module payment milestones, and will serve as the operation backbone connecting nonclinical, CMC, clinical, and regulatory work streams. This position reports to the PERC Program Director (Winston Yan, CTG Senior Director) and works in close coordination with the Center for Therapeutic Genetics Leadership and the PERC scientific and clinical teams.

The role is based in Cambridge, MA, allowing for occasional remote work.

• Serve as the primary point of contact between the PERC team and the ARPA-H THRIVE Program Manager, Contracts Officer, and associated government personnel.
• Maintain and manage the integrated program Gantt charge across all modules (Mod. 1 nonclinical D&D, Mod. 2 investigational medicine, Mod. 3 pilot and scale), ensuring cross-workstream dependencies are tracked and risks are surfaced early.
• Convene and facilitate regular internal team meetings across Broad, clinical sites, CDMOs, and patient organization partners; prepare agendas, drive decisions, and track action items to closure.
• Coordinate data sharing, technology transfer, and communication protocols among all team members per THRIVE’s Performer Agreement requirements.
• Organize and manage all ARPA-H required reporting, including monthly technical and financial status reports, quarterly reviews, and end-of-module reports; ensure submissions are on time, accurate, and tell a coherent narrative of progress.

• Track progress against THRIVE’s defined milestones, metrics, and point system across all modules, and flag payment risks in advance.
• Provide monthly financial reports and other requested materials to ARPA-H contract and program officers as requested.
• Partner with sponsored research teams at the Broad and PERC partner institutions to manage the program budget, monitor burn rate against the milestone payment schedule, and support cost-share tracking.
• Coordinate vendor and CDMO deliverables and nonclinical study timelines against the critical path to IND.

• Support regulatory strategy efforts in coordinating regulatory submissions and meeting logistics, including INTERACT, pre-IND, IND, and any parallel FDA interactions.
• Ensure that all regulatory correspondence and public disclosure deliverables are documented, tracked, and submitted within required time frames based on receipt of regulatory feedback.
• Coordinate IBC, IACUC, IRB, and any other assurance documentation across performing…