Manager, Genetic Product Quality; Fully Remote — Variant Interpretation

Manager, Genetic Product Quality (Variant Interpretation) — Remote

Remote

We are seeking a Manager, Product Quality (Variant Interpretation) to lead the scientific rigor, consistency, and scalability of our variant interpretation efforts. This is a high-impact leadership role responsible for ensuring the accuracy and defensibility of data that powers our products, supports clinical decision-making, and informs pharmaceutical research. As curation volume, product complexity, and client engagements grow, this role will serve as the scientific authority for complex variant interpretation while building and leading a high-performing QA function.

You will shape how interpretation is done at scale—driving standards, improving systems, and mentoring a team of scientists.

If you are passionate about genomics, thrive in complex scientific problem-solving, and want to influence both product and patient impact, this is an opportunity to lead from the front.

• Variant Interpretation & Scientific Leadership
• Serve as the final scientific authority for complex or ambiguous variant interpretation cases, including conflicting clinical and functional evidence
• Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications
• Leverage clinical experience to contextualize variant interpretations and ensure clinical relevance and applicability
• Guide evaluation of functional studies and literature to support high-confidence interpretation decisions
• Support high-impact client deliverables, including clinical and pharmaceutical use cases
• Germline experience preferred

• Quality Assurance & Standards Ownership
• Own QA/QC standards across all variant interpretation workflows
• Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria
• Oversee external data quality, including Clin Var submissions and discrepancy resolution
• Manage, mentor, and develop a team of QA scientists and curators
• Provide coaching on interpretation, evidence evaluation, and best practices
• Set clear performance expectations and maintain accountability for quality standards

• Process Improvement & Scalability
• Design, implement, and continuously improve SOPs, QA processes, and workflows
• Identify systemic quality issues and lead solutions that scale across teams and projects
• Balance standardization with flexibility to meet diverse client and product needs

• Cross-Functional Collaboration
• Partner with product, engineering, and leadership to improve tools, workflows, and data quality
• Contribute to broader data and product strategy through scientific expertise

You are a highly experienced variant interpretation expert who combines scientific depth with leadership capability. You’re comfortable making high-stakes decisions in ambiguous situations, and you take ownership of quality, not just your work, but the work of the team.

You bring a strong QA mindset, a bias toward evidence-based decision-making, and a drive to improve systems.

• 5+ years of hands-on variant interpretation experience in a clinical or equivalent setting
• Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)
• Deep expertise applying ACMG/AMP guidelines in complex scenarios
• Strong experience evaluating clinical and functional evidence from scientific literature
• Proficiency in HGVS nomenclature, including normalization and variant disambiguation
• Demonstrated ability to make independent, high-confidence scientific decisions

• Experience with Clin Var submissions and resolving interpretation discrepancies
• Prior people management or strong leadership experience
• Exposure to a broad range of disease areas or gene classes

• Strong scientific judgment, especially in ambiguous or conflicting evidence scenarios
• A rigorous QA mindset with exceptional attention to detail
• Ability to mentor and elevate others
• Process-oriented thinking with a focus on scalability
• Clear, structured communication of complex scientific concepts
• Ownership mentality for quality, team performance, and outcomes

• Own Scientific Quality at Scale:
  Shape how variant interpretation is performed across products, clients, and public data resources.
• Lead and Build:
  Develop a high-performing team and establish systems that scale with the organization.
• Make a Real Impact:
  Your work directly supports clinical decisions, patient outcomes, and pharmaceutical research.
• Tackle Meaningful Complexity:
  Work on challenging, high-impact problems at the intersection of genomics, data, and real-world application.