Senior Distinguished Scientist Transgenic Model and Technology

Position: Senior Distinguished Scientist for Transgenic Model and Technology
*
* Job title:

** Senior Distinguished Scientist for Transgenic Model and Technology

*
* Location:

** Cambridge, MA

** About the job*
* The Translational In Vivo Models (TIM) department within Sanofi's R&D is seeking an exceptional  
** Senior Distinguished Scientist
** to lead our Transgenic Model & Technology (TMT) function globally. This strategic leadership role will drive innovation in genome engineering and genetically modified model development to accelerate drug discovery across all therapeutic divisions.

As the  
** G*
* ** lobal Head of Transgenic Biology** , you will ensure our organization remains at the forefront of technical developments in genome engineering, enabling breakthrough discoveries in immunology, immuno-inflammation, rare diseases, neuroscience, and oncology. You will serve as a key scientific advisor and strategic thinker, shaping the direction of in vivo and preclinical research programs while championing the integration of emerging technologies - including AI and digital platforms - into transgenic science.

This role is based in  
** Cambridge, MA
** and is primarily office/lab-based with some scope for flexible remote working.

** Key Responsibilities*
* ** Scientific Leadership & Innovation*
* - Lead and advance state-of-the-art genome engineering techniques and mouse genetics applications for in vivo model development supporting discovery and developmental research

- Apply personal expertise in transgenesis and CRISPR technology to devise and execute sophisticated experimental strategies for target validation, proof-of-concept, and efficacy studies

- Identify, evaluate, and implement new technologies and innovations in transgenesis, CRISPR/Cas systems, and emerging genome engineering platforms

- Serve as a  
** strategic thinker and scientific advisor
** to research projects across therapeutic areas, providing expert guidance on in vivo and preclinical study design

- Champion the integration of  
** AI and digital technologies
** to enhance model design, data analysis, and predictive capabilities in transgenic research

- Cover a broad scientific scope including immunology and immuno-inflammation, rare diseases, neuroscience, molecular and immune-oncology, and all areas of cell and molecular biology pertaining to immunology and immune-oncology

** Strategic Planning & Cross-Functional Leadership*
* - Demonstrate  
** strategic thinking and orientation
** in aligning transgenic capabilities with organizational research priorities and long-term scientific goals

- ** Lead and coordinate transversal teams and projects
** across multiple therapeutic divisions, sites, and external partners

- Collaborate closely with the Head of Transgenic Division, drug discovery program leaders, cluster heads, and department heads to provide strategic scientific advice

- Drive budget planning, forecasting, and financial management to optimize resource allocation and operational efficiency

** Operational Excellence & Partnership Management*
* - Establish and maintain comprehensive project management frameworks ensuring full-service delivery from model design through study-ready animal production

- Build and manage strategic relationships with model providers, CROs, and academic partners for development and delivery of genetically modified models

- Negotiate and oversee license agreements and partnership contracts for model acquisition and technology access

- Implement quality standards and continuous improvement initiatives to maintain operational excellence

** People Leadership & Development*
* - Supervise, mentor, and develop staff members to build a high-performing team at the forefront of transgenic science

- Participate in talent management decisions including hiring, promotions, performance evaluations, and organizational development

- Foster a culture of scientific excellence, innovation, collaboration, and continuous learning

** Minimum

Education and Experience Required*
* - Ph.D. in Molecular Biology, Genetics, Developmental Biology, or a related discipline

- Extensive post-doctoral or industry experience in mouse molecular genetics and transgenic animal model development

- Demonstrated track record of scientific…