Director, Clinical Scientist

Company Description

About Bicycle Therapeutics

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development.

The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radio conjugates (BRCs) and imaging agents; zelenectide pevedotin (formerly BT8009), a BDC® targeting Nectin-4, a well-validated tumor antigen; and, through various partnerships, the use of Bicycle® technology to develop therapies to treat diseases in a range of therapeutic areas.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous
  . We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission
  . You can’t change the world if you don’t have determination.
• We are One Team
  . We only succeed when we work together.

Working Classification:

At Bicycle, we benefit from a hybrid style working arrangement, allowing employees where possible the opportunity to collaborate and engage with their coworkers in person while also benefiting from the flexibility of remote working. A typical hybrid arrangement for this role is 3 days onsite per week at our Lexington, MA office, with the remainder of your working week remote.

THE ROLE (The Mission)

Your mission is to serve as a clinical science leader for one of our innovative programs. You will apply your deep expertise in trial design, data interpretation, and translational science to drive our novel assets from early clinical development through to pivotal studies. As the key scientific partner to the physician lead, you will shape clinical strategy and ensure the rigorous execution of trials that will define the future of our therapies and bring them to patients in need.

YOUR RESPONSIBILITIES

• Clinical Trial Strategy & Design:
  • Lead the scientific design of clinical studies, providing expert input on study endpoints, patient population, and biomarker strategies.
  • Serve as the scientific author for clinical trial protocols and amendments, ensuring they are aligned with the overall program strategy and incorporate key principles of clinical development.
  • Maintain a deep and current understanding of the competitive and scientific landscape to ensure our trial designs are innovative and effective.
• Data Analysis & Interpretation:
  • Lead the ongoing, rigorous review and interpretation of clinical trial data, including safety, efficacy, pharmacokinetics, and translational data.
  • Translate complex datasets into clear scientific narratives and actionable insights, guiding critical program decisions such as dose escalation and cohort expansion.
  • Partner with Biometrics and Translational Science to develop and execute analysis plans that fully explore trial data.
• Scientific & Program Leadership:
  • Serve as the primary clinical science expert for assigned programs, acting as the key partner to the Clinical Lead (MD) and the broader development team.
  • Drive the scientific content for key clinical and regulatory documents, including Investigator's Brochures, Clinical Study Reports, and…