Manager, IT G&A Cambridge, MA

Manager, IT Business Applications - G&A Systems

Cambridge, MA

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

We are seeking a highly organized, systems-minded Manager of IT Business Applications for G&A to support day-to-day operations for Amylyx’s HR, Finance, Legal, and Procurement systems, with Net Suite ERP as the primary focus. This customer-facing role will support, maintain, and enhance business applications partner cross-functionally to improve processes, and user experience.

Responsibilities

• Support day-to-day Net Suite activities such as purchasing, receiving, fulfillment, warehouse, and other related Finance/Supply Chain processes.
• Support successful implementations, administration, and ongoing support of Amylyx G&A business applications.
• Partner with HR, Finance, Legal, Procurement, Supply Chain, and IT stakeholders to gather requirements, analyze workflows, document business processes, and translate needs into practical system and operational solutions.
• Support change management, governance, testing, user acceptance activities, and implementation of enhancements in accordance with business needs and IT procedures.
• Ensure appropriate IT processes, procedures, standards, controls, and documentation practices are followed, including support for audit activities as needed.

Required Qualifications

• Bachelor’s degree in computer science, information systems, business, or a related field.
• 5+ years of IT experience with progressively increasing technical, business analysis, and application support responsibilities
• 3+ years of hands‑on ERP experience, such as enhancement projects, data management, and process improvements. Net Suite strongly preferred.
• Hands‑on experience with Net Suite Inventory Management or comparable ERP functionality, including item master data, inventory adjustments, transfers, receipts, fulfillments, and inventory reporting.
• Ability to troubleshoot system and transaction issues, identify root causes, and partner with business users to resolve errors.
• Excellent verbal and written communication skills, with the ability to interact professionally with executives, managers, subject matter experts, business users, IT colleagues, and external partners.
• Strong customer service orientation, attention to detail, data accuracy, and commitment to strong system hygiene.
• Experience supporting regulated environments, such as pharmaceutical, biotech, medical device, or SOX‑controlled environments.

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.
• You will be…