Assistant Director, Sales & Operations Execution Planning

Assistant Director, Sales & Operations Execution Planning

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

Assistant Director, S&OE (Sales & Operations Execution) Planning is responsible for the short-term execution of the supply plan to ensure uninterrupted product availability and optimal inventory management. This role acts as the primary operational liaison between internal stakeholders and external manufacturing and supply partners, driving execution excellence across supply planning, vendor management, material flow, and issue resolution.

They are also responsible for managing supply risks, responding rapidly to supply challenges, coordinating vendor performance, and ensuring accurate execution of supply plans to support customer demand and business objectives.

In addition, the role is responsible for ensuring Clinical Supply requirements are fully incorporated into operational planning processes. This includes monitoring clinical demand forecasts, ensuring product availability for clinical studies, coordinating shipments to clinical depots and study sites, and managing supply risks that could impact clinical trial continuity.

This position may be located in Boston, MA, USA or Dublin, Ireland.

Key Responsibilities:

• Execute and maintain the short-term supply plan to support customer demand, clinical requirements and inventory targets.
• Monitor supply performance and proactively identify potential risks to supply continuity.
• Coordinate cross-functional activities to resolve supply constraints and execution issues.
• Ensure alignment between demand requirements and supply availability.
• Prioritise supply allocation decisions to support both commercial and clinical needs.

• Serve as the primary supply planning contact for Clinical Supply Operations.
• Ensure clinical demand forecasts and study requirements are incorporated into supply plans.
• Monitor inventory availability to support ongoing and upcoming clinical studies.
• Coordinate the timely shipment of clinical materials.

• Serve as the primary operational contact for assigned external manufacturing and supply partners.
• Build and maintain strong vendor relationships to support reliable product supply.
• Lead regular vendor review meetings and operational discussions.
• Escalate and manage supply issues impacting delivery performance.

• Issue rolling forecasts to external manufacturing and supply partners.
• Ensure forecast accuracy and timely communication of changes in demand requirements.
• Coordinate forecast reviews and challenge assumptions where appropriate.

• Provide rapid response to supply…