Executive Director, Clinical Operations

Join Immatics and shape the future of cancer immunotherapy; one patient at a time! Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Innovative Environment:
Help to pioneer advancements in cancer immunotherapy. Collaborative Culture:
Be part of a diverse team dedicated to your professional growth. Global Impact:
Contribute to therapies that make a lasting impact on patients globally.

The Executive Director, Clinical Operations serves as the operational deputy and strategic partner to the VP, Clinical Operations. This high-impact executive role provides integrated leadership across the entire clinical operations ecosystem. You will translate high-level clinical strategy into seamless portfolio delivery, scalable organizational capability, and robust global execution. As a systems-builder and visionary leader, you will run today’s global clinical portfolio with operational excellence while simultaneously building the capabilities required for tomorrow's late-stage development and commercialization.

Location:

Global (US / Germany; Remote)

Reports To:

Vice President, Clinical Operations

Salary Range: $270,000 to $300,000

Basic Qualifications:

Bachelor’s degree in a scientific, nursing, or business discipline required; 15+ years of clinical research experience within a biotech, pharmaceutical, or major CRO environment, including 7+ years in a senior, multi-functional leadership capacity.

Preferred Qualifications:

Advanced degree (MD, PhD, PharmD, MS, or MBA) preferred. Direct operational experience managing Cell Therapy, Immuno-Oncology, or advanced therapeutic modality trials is a strong plus. Directly manage and inspire a geographically dispersed, multicultural clinical operations teams, with specific focus on harmonizing workflows between US and European (Germany) team members. A natural "systems builder" who thrives on creating infrastructure, optimizing workflows, and designing scalable processes.

Demonstrated track record of leading multiple dimensions of clinical operations (e.g., trial management, data/systems, sample logistics, site monitoring). Extensive experience leading complex, global clinical trials across North America and Europe (experience with US/Germany structures is highly desirable). Deep experience navigating clinical operations in Oncology is required. Proven experience driving Phase III registrational trials, global regulatory filings (BLA/NDA/MAA submissions), and preparing operations for commercialization.

Demonstrated experience leading Clinical Operations within a biopharmaceutical organization with strong understanding of internal clinical operations, trial execution and regulatory requirements. Sophisticated experience managing large-scale CRO partnerships and vendor governance committees. Strong communication and influencing skills, with the clear capability