Senior Distinguished Scientist Transgenic Model and Technology

Job title:

Senior Distinguished Scientist for Transgenic Model and Technology

Cambridge, MA

The Translational In Vivo Models (TIM) department within Sanofi's R&D is seeking an exceptional Senior Distinguished Scientist to lead our Transgenic Model & Technology (TMT) function globally. This strategic leadership role will drive innovation in genome engineering and genetically modified model development to accelerate drug discovery across all therapeutic divisions. As the Global Head of Transgenic Biology, you will ensure our organization remains at the forefront of technical developments in genome engineering, enabling breakthrough discoveries in immunology, immuno‑inflammation, rare diseases, neuroscience, and oncology.

You will serve as a key scientific advisor and strategic thinker, shaping the direction of in‑vivo and preclinical research programs while championing the integration of emerging technologies — including AI and digital platforms — into transgenic science. This role is based in Cambridge, MA and is primarily office/lab-based with some scope for flexible remote working.

• Lead and advance state‑of‑the‑art genome engineering techniques and mouse genetics applications for in‑vivo model development supporting discovery and developmental research.
• Apply personal expertise in transgenesis and CRISPR technology to devise and execute sophisticated experimental strategies for target validation, proof‑of‑concept, and efficacy studies.
• Identify, evaluate, and implement new technologies and innovations in transgenesis, CRISPR/Cas systems, and emerging genome engineering platforms.
• Serve as a strategic thinker and scientific advisor to research projects across therapeutic areas, providing expert guidance on in‑vivo and preclinical study design.
• Champion the integration of AI and digital technologies to enhance model design, data analysis, and predictive capabilities in transgenic research.
• Cover a broad scientific scope including immunology and immuno‑inflammation, rare diseases, neuroscience, molecular and immune‑oncology, and all areas of cell and molecular biology pertaining to immunology and immune‑oncology.
• Demonstrate strategic thinking and orientation in aligning transgenic capabilities with organizational research priorities and long‑term scientific goals.
• Lead and coordinate transversal teams and projects across multiple therapeutic divisions, sites, and external partners.
• Collaborate closely with the Head of Transgenic Division, drug discovery program leaders, cluster heads, and department heads to provide strategic scientific advice.
• Drive budget planning, forecasting, and financial management to optimize resource allocation and operational efficiency.
• Establish and maintain comprehensive project management frameworks ensuring full‑service delivery from model design through study‑ready animal production.
• Build and manage strategic relationships with model providers, CROs, and academic partners for development and delivery of genetically modified models.
• Negotiate and oversee license agreements and partnership contracts for model acquisition and technology access.
• Implement quality standards and continuous improvement initiatives to maintain operational excellence.
• Supervise, mentor, and develop staff members to build a high‑performing team at the forefront of transgenic science.
• Participate in talent management decisions including hiring, promotions, performance evaluations, and organizational development.
• Foster a culture of scientific excellence, innovation, collaboration, and continuous learning.

• Ph.D. in Molecular Biology, Genetics, Developmental Biology, or a related discipline.
• Extensive post‑doctoral or industry experience in mouse molecular genetics and transgenic animal model development.
• Demonstrated track record of scientific leadership in an academic or pharmaceutical/biotech research environment.
• Minimum of 5 years of demonstrated, hands‑on experience performing this role.

• Deep expertise in developing transgenic animal models, including engineering diverse genetic…