Research Fellow

Job Summary

In this position, the candidates will learn strategies and techniques for LC-MS analysis, drug optimization and lead drug candidate selection, pharmacokinetics and drug metabolism, clinical sample analysis and clinical pharmacokinetics, and mass spectrometry imaging of small molecules, endogenous metabolites, lipids, proteins on tissue sections.

• LC-MS bioanalysis method development, validation, and samples analysis to clinical studies, which focus on a phase 1 single dose study to evaluate the pharmacokinetic and local GI drug release/dissolution of new drug formulation.
• Metabolite identification using LC-MS/MS in microsomal incubation and in vivo biological matrix.
• Mass spectrometry imaging of small molecules from tissue samples.
• Quantitative LC-MS analysis of compounds in biological matrix of preclinical samples.
• Lead optimization, in vitro preclinical studies and clinical pharmacokinetic analysis.
• In-vivo animal PK study samples analysis by working with animal team.
• Targeted metabolomics studies for routine quantitation of well characterized metabolites, or untargeted metabolomics to discover biomarkers.
• Independent preparation of study reports.

• PhD degree in analytical chemistry, chemistry, pharmaceutical sciences, pharmacology and related fields.
• LC-MS skills, knowledge, and experience for small or large molecules are required.
• The candidate should be a good team player with strong oral and written communication skills.
• Knowledge and experience in metabolite identification and pharmacokinetics are preferred.
• Knowledge and experience in high resolution mass spectrometry is preferred.
• Knowledge and experience in mass spectrometry imaging with MALDI is a plus.
• Ability to work closely with others in a small team setting.

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.