Research Scientist - Protein Sciences

Research Scientist – Protein Sciences

As a Research Scientist on our Antibody Discovery team, you will play a critical role in advancing Elanco's pipeline by producing high-quality proteins essential for groundbreaking structural biology studies. In this lab-based role, you will lead protein production for parasitology, small molecule, and large molecule projects, tackling complex expression challenges and mastering automated purification systems. This is an exciting opportunity to directly contribute to the discovery of novel animal health solutions.

Your Responsibilities:

• Design and execute multi-platform protein expression and purification strategies (bacterial, insect, mammalian) for structural biology studies.
• Develop, optimize, and troubleshoot protocols for automated chromatography (AKTA) and various purification techniques, including Affinity (NiNTA, GST), Ion Exchange (IEX), and Size Exclusion Chromatography (SEC).
• Employ advanced genetic construct design (e.g., tag selection, truncation screening, codon optimization) to enhance protein solubility and suitability for structural biology studies.
• Serve as the technical point of contact for outsourced protein production projects with external Contract Research Organizations (CROs), ensuring quality and timeline standards are met.
• Maintain rigorous and timely documentation of all experimental procedures and results within the Electronic Laboratory Notebook (ELN) system.

What You Need to Succeed (minimum qualifications):

• Education:
  
  Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related scientific field.
• Experience:
  
  Foundational hands-on experience in recombinant protein expression and purification, typically gained through academic research (0-2 years).
• Top
  
  Skills:
  
  Demonstrated expertise in common protein expression/purification techniques and a strong aptitude for independent experimental design and troubleshooting.

What will give you a competitive edge (preferred qualifications):

• Familiarity with preparing and characterizing proteins specifically for X-ray crystallography or Cryo-EM.
• Direct experience with challenging targets such as membrane proteins (e.g., GPCRs, ion channels).
• Working knowledge of protein refolding methods from inclusion bodies.
• Experience in generating and evaluating stable cell lines for protein expression.

Additional Information:

• Location:
  
  Global Elanco Headquarters
  - Indianapolis, IN
• Work Model:
  Hybrid
  - This position is based in Indianapolis and requires a blend of on-site and remote work.
• Travel:
  Less than 10%

Don't meet every single requirement? Studies have shown under recognized groups are less likely to apply to jobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role but don't necessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles!

Elanco Benefits and Perks:

• Multiple relocation packages
• Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)
• 8-week parental leave
• 9 Employee Resource Groups
• Annual bonus offering
• Flexible work arrangements
• Up to 6% 401K matching

Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.