Research Associate I ​/ Research Associate II, Manufacturing Process Research

Research Associate I / Research Associate II, Manufacturing Process Research

Job Category
:
Manufacturing & Operations - Ionis

Requisition Number
: IONIS
004100

• Posted :
  August 14, 2026
• Full-Time

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Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

RESEARCH ASSOCIATE I / RESEARCH ASSOCIATE II, MANUFACTURING PROCESS RESEARCH

WORK LOCATION Carlsbad, CA

ABOUT THE TEAM:

Ionis Pharmaceuticals is a leader in RNA-targeted medicines. Our Manufacturing & Operations organization develops and manufactures oligonucleotide drug substance and drug product to support clinical development and commercial programs. The Development Chemistry team works at the interface of chemistry, process development, analytical science, and manufacturing to turn promising molecular designs into robust, scalable processes.

The team supports a broad range of modalities, including antisense, siRNA, modified oligonucleotides, and peptide-conjugated compounds, while evaluating new reagents, solid supports, purification strategies, and process technologies. This work connects laboratory scale research with manufacturing campaigns and cross-function chemistry, manufacturing, and control activities.

Ionis is a lean, knowledgeable-based organization that values direct communication, thoughtful technical debate, cross-functional collaboration, and employee ownership. Team members work across functions and levels to solve problems efficiently, contribute to meaningful development programs, and grow through increasing scope, responsibility, and impact.

POSITION SUMMARY:

The Research Associate or Research Associate II, Manufacturing Process Research role will support the development and execution of laboratory-scale oligonucleotide manufacturing processes. This entry-level scientist will work under the direction of experienced scientists and project leads to perform defined experiments, prepare and purify oligonucleotide materials, review analytical data, and document results in electronic laboratory notebooks and technical reports. The role is expected to contribute to experiments and technical deliverables;

it is not initially responsible for independently setting final manufacturing parameters, approving GMP decisions, leading complex experimental programs, managing external organizations, or serving as the technical owner of a major project.

The role offers broad exposure to solid-phase oligonucleotide synthesis, cleavage and deprotection, conjugation, purification, annealing, filtration, and related process operations. The…