Remote | ADC & Bispecific Antibody R&D Scientist

Specialised Part-Time Consulting Opportunity

We are sharing a specialised part-time consulting opportunity for experienced preclinical R&D scientists with hands-on expertise in antibody-drug conjugates (ADCs), bispecific or multispecific antibodies, and in-house drug development.

This role supports a research initiative focused on improving how advanced computational systems reason about real-world biologics discovery and preclinical development. Selected experts will review scientific materials and programme data, evaluate technical outputs, contribute practical judgement on modality and development decisions, and help define high-quality data structures grounded in authentic ADC and bispecific R&D workflows.

ADC & Bispecific Programme Review

• Review technical materials and scientific data from ADC, bispecific, and multispecific antibody programmes
• Evaluate whether analyses and conclusions reflect realistic preclinical development practice
• Identify weak assumptions, unsupported claims, and biologically implausible outputs
• Apply hands-on programme experience to complex development scenarios
• Assess trade-offs involving efficacy, safety, develop ability, manufacturability, and programme risk

Target & Modality Strategy

• Evaluate target-selection and modality-selection decisions
• Assess biological rationale, therapeutic hypothesis, and competitive differentiation
• Review trade-offs between ADC, bispecific, multispecific, and other biologic approaches
• Identify risks associated with target biology, expression patterns, mechanism of action, or therapeutic window
• Apply practical judgement to programme progression and prioritisation decisions

ADC Development

• Contribute expertise across antibody selection, linker strategy, payload choice, conjugation, and overall ADC design
• Evaluate potency, selectivity, internalisation, stability, exposure, and toxicity considerations
• Review development decisions affecting efficacy and therapeutic index
• Assess preclinical evidence supporting candidate progression
• Identify common failure modes and optimisation challenges in ADC programmes

Bispecific & Multispecific Antibodies

• Review programmes involving bispecific or multispecific antibody architectures
• Evaluate target combinations, binding strategy, format selection, and functional activity
• Assess develop ability, PK/PD, immunogenicity, safety, and manufacturability considerations
• Review translational evidence and candidate-selection decisions
• Identify modality-specific risks that may affect progression toward the clinic

Preclinical & Translational Development

• Apply experience across in vitro, in vivo, translational, pharmacology, and PK/PD workflows
• Evaluate experimental design and interpretation of preclinical evidence
• Assess how findings influence candidate optimisation and development strategy
• Review programme readiness for lead optimisation or IND-enabling development
• Identify evidence gaps, unresolved risks, and appropriate next-stage studies

Cross-Functional R&D Expertise

• Contribute expertise from areas such as:
  • Discovery biology
  • Medicinal chemistry
  • Protein and antibody engineering
  • Computational drug discovery
  • In vivo and translational research
  • Pharmacology and PK/PD
  • Toxicology
  • CMC and formulation
• Apply cross-functional judgement to integrated programme decisions
• Evaluate how findings from different disciplines affect candidate selection and development

Scientific Data Evaluation

• Label, classify, and annotate scientific data and technical outputs
• Identify meaningful experimental signals, development decisions, and failure modes
• Evaluate the relevance and quality of information used in downstream research workflows
• Help establish consistent standards for scientific review and annotation
• Translate practical R&D expertise into structured, usable data

Dataset & Research Development

• Help define structure and quality standards for scientific data pipelines
• Identify which experimental and development variables should be captured
• Surface workflow details that are often missed outside hands-on preclinical R&D
• Participate in expert discussions, interviews, and research engagements
• Provide practical perspective on how biologics programmes are advanced in industry

• 5+ years of relevant pharmaceutical or biotechnology R&D experience, with flexibility for candidates demonstrating exceptional technical depth
• Hands-on, non-administrative preclinical R&D experience within a company developing its own therapeutic assets
• Direct professional experience with ADCs and/or bispecific or multispecific antibodies
• Experience at an organisation that has advanced internal drug programmes toward or into clinical development
• Current or recent work in a core R&D function such as discovery biology, medicinal chemistry, protein or antibody engineering, computational discovery, translational science, pharmacology, PK/PD, toxicology, or CMC
• Strong understanding of biologics discovery, optimisation, and preclinical development
• Experience advancing a programme through lead optimisation,…