Postdoctoral Scholar - Dermatology

APPLICATION INSTRUCTIONS:

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CURRENT PENN STATE STUDENT (not employed previously at the university) and seeking employment with Penn State, please login to Workday to complete the student application process. Please do not apply here, apply internally through Workday.

If you are NOT a current employee or student, please click “Apply” and complete the application process for external applicants .Approval of remote and hybrid work is not guaranteed regardless of work location. For additional information on remote work at Penn State, see Notice to Out of State Applicants .This is a term position; length of the term will be discussed during the interview process.

Continuation past the term length discussed will be based on university need, performance, and/or availability of funding.

POSITION SPECIFICS The laboratory of Dr. Ryan Hobbs in the Penn State College of Medicine, Department of Dermatology, is seeking a full-time Postdoctoral Scholar to work on campus in Hershey, Pennsylvania.

Research in the Hobbs Laboratory focuses on understanding how epithelial cells sense and respond to cellular, environmental, and inflammatory stress. Using skin keratinocytes as a primary model system, the laboratory investigates the molecular mechanisms that regulate epithelial survival, differentiation, cell adhesion, tissue repair, and disease development. Current projects integrate advanced light microscopy, cell and molecular biology, functional genomics, and drug-discovery approaches to identify pathways that control keratinocyte stress responses and to evaluate potential therapeutic modifiers of epithelial dysfunction.

The successful applicant will lead research projects employing advanced fluorescence and live-cell microscopy techniques to investigate dynamic cellular and molecular processes in keratinocytes. The position will also involve the development and implementation of targeted and higher-throughput drug-discovery screening approaches, including assay optimization, compound testing, quantitative imaging, and validation of candidate therapeutic agents.

Applicants should possess pronounced expertise in keratinocyte biology and a strong foundation in cellular and molecular biology. Demonstrated experience with mammalian cell culture, fluorescence microscopy, quantitative image analysis, biochemical assays, and molecular biology techniques is strongly preferred.

Experience with advanced light microscopy, automated imaging, drug or small-molecule screening, three-dimensional epithelial culture models, primary cell culture, or mouse skin biology is desirable.

Responsibilities
• Independently design, conduct, analyze, and interpret experiments related to assigned research projects.
• Apply advanced light microscopy approaches, including fluorescence, confocal, live-cell, and quantitative imaging techniques.
• Develop and execute drug-discovery and small-molecule screening assays using keratinocyte and epithelial model systems.
• Establish, optimize, and troubleshoot cellular, molecular, biochemical, and imaging-based experimental methods.
• Maintain and experimentally manipulate primary and immortalized keratinocyte cultures and other relevant epithelial model systems.
• Analyze microscopy, molecular, and functional screening data using appropriate quantitative and statistical approaches.
• Seek out new scientific resources and learn or develop new techniques as warranted by project needs.
• Maintain accurate and complete experimental records and contribute to laboratory data-management practices.
• Present scientific findings at laboratory meetings, departmental seminars, scientific conferences, and other professional venues.
• Prepare scientific manuscripts, abstracts, reports, and other research-related documents.
• Contribute to the development of grant applications and future research directions.
• Train and mentor graduate students, undergraduate students, and other laboratory personnel.
• Contribute positively to…