Director or Senior Director of Translational Medicine

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Director or Senior Director of Translational Medicine

Director or Senior Director of Translational Medicine
Fully Remote Remote - Nationwide

BBOT is a clinical-stage biopharmaceutical company advancing a next-generation pipeline of novel small molecule therapeutics targeting RAS and PI3K malignancies. BBOT has the goal of improving outcomes for patients with cancers driven by the two most prevalent oncogenes in human tumors. For more information visit

We are seeking a Director or Senior Director, Translational Medicine to serve as BBOT’s embedded translational medicine lead across its early-phase oncology programs, with a primary focus on RAS and PI3K-driven malignancies. Reporting to the CMO/CDO, this scientist will own translational and biomarker strategies from IND-enabling studies through proof of concept, operating at the intersection of biology, clinical data, and regulatory science.

This is a hands‑on, execution‑oriented role for a deep expert in translational oncology who is energized by the pace and impact of a lean, early‑stage biotech. Level of appointment will be commensurate with experience.

• Serve as the dedicated translational medicine lead for assigned BBOT programs, defining and owning biomarker and translational strategies, plans, and decision-enabling datasets from preclinical through Phase 1/proof-of-concept
• Provide scientific input into target validation, pharmacology, PK/PD, target engagement, mechanism of action, and patient selection strategies; integrate preclinical findings with clinical development plans to inform dose selection, biomarker endpoints, and go/no‑go criteria
• Evaluate emerging data from ongoing studies to generate and test hypotheses, define mechanisms of resistance, and adapt translational strategies in real time to support program advancement and reverse translation efforts
• Serve as the primary translational interface on cross-functional program teams, representing translational perspectives in clinical project teams, program governance, and portfolio reviews; translate complex biomarker evidence into clear risk/benefit and go-to-clinic recommendations

• Design, develop, and oversee hypothesis-driven biomarker plans including assay strategy (fit-for-purpose), sample collection and handling procedures, and statistical/analysis plans; lead assay selection, qualification/validation strategy, and oversight via internal or external partners
• Oversee clinical biomarker implementation: sample collection strategies, laboratory manuals, biomarker sections of clinical study protocols, informed consent forms, and analysis plans for first-in-human and early-phase studies
• Partner with clinical operations and external CROs, academic labs, and diagnostic partners to ensure robust sample logistics, data generation, documentation, and regulatory/quality readiness of all biomarker deliverables; oversee junior biomarker operations employees as assigned
• Ensure biomarker data and outputs meet quality standards for inclusion in clinical study reports, regulatory filings (INDs, briefing packages, NDAs), and scientific publications; serve as subject matter expert in health authority interactions involving translational and biomarker content
• Identify and incorporate emerging biomarker technologies and scientific advances into BBOT’s translational approaches, including ctDNA/liquid biopsy, NGS, IHC/IF, and multi-omic platforms; engage external scientific collaborators and technology partners as needed

• Prepare and present translational updates,…