Senior or Principal Scientist: Synthetic Chemistry & Bioconjugation

The Position

We are seeking an exceptional synthetic chemist to help develop the next-generation of oligonucleotide medicines designed for delivery beyond the liver.

We are seeking an exceptional synthetic chemist to help develop the next-generation of oligonucleotide medicines designed for delivery beyond the liver.

This role bridges solid-phase oligonucleotide synthesis, novel RNA and DNA chemistries, and delivery-enabling bioconjugation.

Depending on your expertise and interests, you may focus on synthesizing oligonucleotides, delivery ligands, or linkers or on developing conjugated therapeutic candidates.

You will join a growing team of 25 chemists, cell biologists, and in vivo biologists in our 20,000-square-foot R&D facility outside Washington, D.C.

You have a PhD in Chemistry, Materials Science, or a related discipline and a strong record of scientific accomplishment.

You should have deep expertise in one or more of the following:

Experience with solid-phase synthesis, deprotection, purification, and characterization of RNA or DNA oligonucleotides, including siRNA, ASOs, or related modalities. Experience with backbone, sugar, base, and terminal modifications is highly valued. Substantial experience with solid-phase peptide synthesis or related synthetic platforms is also relevant, particularly for ligand synthesis, linker installation, or conjugate development.

Experience designing, synthesizing, and optimizing bioconjugates to improve delivery, biodistribution, pharmacokinetics, cellular uptake, or in vivo potency. These may include conjugates incorporating oligonucleotides, peptides, antibodies, small molecules, carbohydrates, lipids, polymers, or other targeting moieties. Experience synthesizing or optimizing GalNAc, carbohydrate, peptide, lipid, polymer, or other ligand-conjugated candidates is highly valued.

Experience developing or applying functionalized CPGs, synthesis supports, protected ligands, linkers, attachment handles, or on-column strategies to install delivery ligands onto oligonucleotides. Experience with solution-phase or post-synthetic conjugation, site-selective functionalization, orthogonal protecting groups, or bioorthogonal chemistry is also highly valued.

Experience with LC-MS and HPLC to assess candidate identity, purity, yield, and product quality. Experience with ion-exchange chromatography, reversed-phase chromatography, SEC, PAGE, or related analytical methods is also highly valued.

• Experience supporting synthetic chemistry process development, scale-up, technology transfer, CDMO management, or cGMP manufacturing.
• Experience with cleavable and non-cleavable linker designs, including enzymatic, redox-sensitive, acid-labile, or related release strategies.
• Experience developing modified CPGs, phosphoramidites, activated esters, azide–alkyne click chemistry, amine- or thiol-reactive handles, or related approaches for solid-phase, on-column, or post-synthetic conjugation.
• Experience with formulation or particle-engineering approaches relevant to nucleic acid therapeutics, including spray drying, lyophilization, dry-powder inhalation, or controlled release.
• Experience testing therapeutic candidates in vitro or in vivo and using biological results to guide chemical design.

PhD required

5+ years of relevant R&D experience, including PhD work

Rockville, MD (on-site)