Lead Scientific Developer – Biologics & Protein Design

At Cadence, we hire and develop leaders and innovators who want to make an impact on the world of technology.

Open Eye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software‑as‑a‑service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances.

• Work on challenging problems and help find practical solutions that advance the field of computational biologics drug discovery
• Develop highly scalable and integrated solutions for biologics drug discovery in the cloud
• Develop data‑driven models using sequence and 3D molecular shape representations leveraging AI and physics‑based approaches
• Expand Open Eye’s biomolecular modeling and protein informatics technologies
• Collaborate with great colleagues within our group, within Open Eye & Cadence, as well as within the broader pharmaceutical industry on developing new methods, tools, and solutions

• PhD (or equivalent experience) in computational chemistry, structural biology, biochemistry, or related field with at least 5 years relevant experience
• Strong desire to change the field of biologics drug discovery through hard work, creating robust software tools, and critical scientific evaluation
• Demonstrated ability to work both independently and as part of a team. Ability to work humbly with others, admitting mistakes and constructively working through differences in opinion
• Experience with molecular dynamics simulations and machine learning
• Programming expertise, ideally in Python, preferably with experience using AI coding agents
• Proven track record of delivering software solutions

• Expertise with traditional machine learning and/or modern deep learning methods
• Experience with Open Eye software/toolkits or other computational chemistry toolkits
• Experience with protein language models and protein folding technologies
• Experience with modeling antibodies based on sequence and structural data

Cadence is committed to equal employment opportunity throughout all levels of the organization. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, basis of disability, or any other protected class.