Senior Security Engineer

## Senior Security Engineer Apply locations:
Palo Alto, CA:
Remote - Open Position (USA) time type:
Full time posted on:
Posted Todayjob requisition :
R-100695
** Company Description
** Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.

For more information, visit  and follow the company on Linked In, X (Twitter) and Facebook.
** Company Description
** Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through the use of its proprietary blood tests, vast data sets, and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes, and lower healthcare costs across all stages of the cancer care continuum.

** Job Description
** The Senior Security Engineer, reporting to the Associate Director of Security Engineering, will be responsible for designing, implementing, operating, and continuously improving Guardant Health’s core security capabilities. This role is broad and hands-on, spanning Security Tooling, Logging and Monitoring, Threat Detection, Incident Response, Vulnerability Management, Cloud Security, Endpoint Security, Identity, and Security Automation.
You will serve as a technical leader within the Security Engineering function, partnering closely with Security Architecture, IT, Cloud Infrastructure teams. This role requires someone comfortable wearing many hats — from managing enterprise security platforms and improving response workflows, to modernizing logging and detection capabilities, supporting investigations, reducing vulnerability risk, and helping mature the company’s overall security posture.

The ideal candidate has strong technical breadth, operational judgment, and the ability to move between engineering, operations, and incident response work in a fast-paced environment. You will help ensure Guardant Health has the right tools, telemetry, processes, and controls in place to detect, prevent, respond to, and recover from security threats. Lastly, the right person will love the technology and be excited to find open source solutions.

** Duties and Responsibilities
*** Design, implement, operate, and continuously improve enterprise security tools across Endpoint, Cloud, Identity, Network, SaaS, Vulnerability Management, Logging, and Response platforms.
* Oversee and optimize Managed Detection and Response (MDR), as well as Security Orchestration, Automation, and Response (SOAR), capabilities and related integrations.
* Serve as a technical owner for SIEM operations, including log source onboarding, data normalization, detection support, performance tuning, cost optimization, and regulatory logging requirements.
* Develop, tune, and maintain high-value Threat Detection content, including SIEM rules, behavioral analytics, endpoint detections, cloud detections, and identity-based alerts.
* Analyze security events, threat intelligence, and attacker tradecraft to improve detection coverage, validate alert effectiveness, and support incident response investigations.
* Support and participate in Incident Response activities, including triage, investigation, containment, eradication, recovery, evidence collection, and post-incident reviews.
*…