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Senior Data Engineer
Job in
Palo Alto, Santa Clara County, California, 94306, USA
Listed on 2026-02-21
Listing for:
Guardant Health
Full Time
position Listed on 2026-02-21
Job specializations:
-
Software Development
AI Engineer, Data Science Manager, Data Engineer
Job Description & How to Apply Below
** Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.
For more information, visitand follow the company on,and.#
Key Responsibilities:
## Data Engineering & Pipeline Development
* Design, build, and maintain large-scale ETL/ELT pipelines using AWS Glue and related AWS services.
* Develop and optimize data models across Amazon S3, Redshift, and Neptune to support analytics and AI workloads.
* Implement transformation and data modeling workflows, ensuring data accuracy, consistency, and lineage.
* Manage data orchestration using Apache Airflow or AWS Step Functions to ensure reliability and timely data delivery.
* Integrate data from CRM platforms, marketing systems, provider datasets, and operational tools into scalable commercial data pipelines.## Agentic AI Application Development
* Build Agentic AI-driven workflows using Agentic AI frameworks such as Langchain, Langgraph, Strands, LLMs and Knowledge Bases
* Develop multi-agent systems that support sales enablement, provider insights, and commercial operations automation.
* Implement retrieval-augmented generation (RAG) pipelines and hybrid search workflows using vector databases and AWS-native retrieval tools.
* Build and maintain Amazon Neptune knowledge graph.
* Integrate agent capabilities with internal systems and APIs to support use cases such as provider briefings, objection handling, triage workflows, and content generation.
* Implement security guardrails and access control for agent tools.
* Develop evaluation, telemetry, and monitoring processes to assess agent performance, detect hallucinations, and ensure workflow stability.## Cross-Functional Collaboration
* Work closely with Product teams, Commercial Operations, Sales and Marketing, Data Engineering, and to identify automation opportunities.
* Translate business requirements into scalable technical solutions with high reliability and security.
* Provide technical leadership and best practices for AI-driven workflow development#
Qualifications:
##
Required Qualifications
* Bachelor’s or Master’s degree in Computer Science, Engineering, Data Science, or a related field, or equivalent experience.
* 5+ years of professional experience in
** data engineering**,
** AI engineering**,
** or related fields**.
* Strong expertise with AWS data engineering technologies, including:
** AWS Glue, Amazon S3, Amazon Neptune/Redshift, Apache Airflow
*** Hands-on experience with agentic AI frameworks such as:
* ** AWS Strands SDK
** and
** Bedrock** (highly preferred)
* Strands SDK, Lang Graph, Lang Chain, CrewAI, or Auto Gen
* Strong proficiency in
** Python
* * and experience with distributed data processing frameworks.
* Practical understanding of LLMs, embeddings, vector search, RAG pipelines, and multi-agent orchestration.
* Experience building secure, reliable workflow systems with attention to guardrails, error handling, and compliance.##
Preferred Qualifications
* Experience integrating data from CRM systems (e.g., Salesforce) or other GTM platforms.
* Experience in commercial operations, sales enablement, healthcare analytics, or diagnostic products.
* Familiarity with healthcare data compliance, including HIPAA and PHI handling.
* Experience with Docker, CI/CD pipelines, Kubernetes, or observability tools (Cloud Watch , Prometheus, Grafana).## Competencies
* Strong analytical and problem-solving skills.
* Ability to work independently in fast-paced, dynamic environments. AI-native builder quick prototype who iterates fast.
* First-principles thinker who chooses tools for correctness and efficiency.
* Excellent communication skills with the ability to collaborate across…
Position Requirements
10+ Years
work experience
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