Senior Product Manager, AI

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real‑world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early‑stage cancer, and treatment selection for patients with advanced cancer.

For more information, visit  and follow the company on Linked In, X (Twitter) and Facebook.

The Senior Product Manager, AI will lead the delivery and evolution of Guardant’s AI product roadmap across both internal operations and customer‑facing experiences. This role is responsible for driving conversational, generative, agentic, and predictive AI solutions that improve operational efficiency, scale service capacity, and elevate provider and patient engagement through intuitive, seamless, and cohesive customer experiences.

Partnering with a diverse cross‑functional team, the Senior PM will ensure AI investments align with Guardant’s strategic priorities while delivering end‑to‑end experiences that are consistent, trusted, and user‑centric across every touchpoint. This individual will play a key role in defining and optimizing CX flows, ensuring AI capabilities are thoughtfully integrated into workflows to reduce friction, simplify complex interactions, and create meaningful experiences for providers, patients, and internal teams alike.

The ideal candidate brings deep knowledge of AI technologies, proven experience translating business and user needs into scalable product solutions, and a strong track record of driving cross‑functional alignment across product, design, engineering, operations, and customer‑facing teams. Success in this role requires both strategic thinking and strong execution, with the ability to influence stakeholders and champion a high‑quality customer experience throughout the product lifecycle.

• Partner with stakeholders and Engineering to define and execute the roadmap for Screening AI solutions.
• Prioritize high‑impact use cases that scale operations, improve provider/patient experiences, and align with Guardant’s strategic objectives.
• Stay ahead of AI and healthcare technology trends to ensure competitive and compliant solutions.

• Lead the full product lifecycle from ideation through launch, adoption, and iteration.
• Translate business needs into clear product requirements and partner with Engineering to deliver solutions.
• Collaborate with cross‑functional teams to deploy customer‑facing AI solutions that streamline communication, create engaging content, and personalize outreach.
• Define and optimize end‑to‑end customer experience (CX) flows across AI‑powered touchpoints, ensuring interactions are intuitive, cohesive, and aligned with provider and patient needs.
• Identify friction points, improve user journeys, and drive measurable improvements in engagement, satisfaction, and service efficiency.
• Partner with Operations to automate workflows, integrate AI into the CRM and support tools, and enable faster, more accurate decision‑making.
• Partner with Compliance and Legal to ensure AI solutions meet regulatory, privacy, and ethical standards.

• Define and track success metrics that demonstrate efficiency gains, customer impact, and scalability.
• Communicate program updates, trade‑offs, and outcomes to executive stakeholders with clarity and influence.

• 7+ years of product management experience, with 2+ in AI/ML‑driven products.
• Strong knowledge of conversational, generative, agentic, and predictive AI applications.
• Proven success delivering AI‑enabled solutions in healthcare, diagnostics, or other regulated industries.
• Deep understanding of healthcare workflows across providers, patients, and operations.
• Exceptional analytical skills, with the ability to tie AI initiatives to…