Director of Biology & Biochemistry

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

** Organization Overview:*
* At Lilly, we serve an extraordinary purpose. For 150 years, we have worked tirelessly to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world's greatest health challenges.

Protomer team at Lilly focuses on chemical biology, molecular switches and oral macrocyclic peptide platforms. This position is for a senior biologist-biochemist with extensive background and knowledge in assay development, protein binding assays and knowledge of mammalian protein expression and characterization.

Successful candidates would lead biology efforts, oversee multiple projects and support the chemistry team with detailed biology knowledge and assay support to accelerate projects.

Work experience and research background on oral macrocycles, oral permeability and potency assays for macrocyclic peptides is highly desired. However the breadth of projects spans both peptide macrocycles biology and assay development as well as responsive therapeutics and peptides.

This position is to lead biology and protein biochemistry efforts, interfacing with many molecule makers to support chemists in molecule testing of compounds and synthesized peptides. The protein biochemist/biologist is expected to have extensive knowledge of supporting drug development campaigns and have ability to identify active compounds and troubleshoot and design biology support for a large team of chemists.

The successful candidate is expected to have mastery of standard molecular biology techniques, cell-based assays, protein purification and characterization as well as in vitro biochemical assays. The candidate is expected to have excellent knowledge of protein binding techniques and demonstrated extensive work with SPR systems and troubleshooting techniques. The candidate is expected to work closely with mammalian protein expression group including external CROs to troubleshoot expression constructs, increase protein yield, and navigate appropriate purification techniques and functional protein characterization.

Protomer team engages in disease-relevant biological systems in order to test preclinical and clinical pipeline of innovative medicines. The candidate is expected to help develop strategy, direction and manage scientific group milestones and objectives based on an ambitious long-term strategic plan which the candidate helps to develop.

The ideal candidate is a significant contributor and leading a highly integrated, agile, and collaborative team effort and expected to manage the scientific portfolio, the business supporting the portfolio, and mentoring of junior scientists within the oral macrocycles group al candidate is expected to have demonstrated success in similar roles with proven track record of leading both scientific rationale, planning and execution leading to success in making medicines.

This individual will also be expected to be able to independently lead projects, help shape the team and strategy of the group, contribute significantly to prioritization of the team objectives and interact with and create and nurture the cross-functional relationships interacting with various therapeutic areas such diabetes and obesity, neuroscience, immunology and oncology.

** Responsibilities:*
* + Contribute as the lead biochemist and assay biologist for the team on macrocyclic discovery, contributing both insight and developing strategy for assays for various…