Advisor of Computational Peptide Biochemistry

Organization Overview

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life‑changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Organization Overview:
At Lilly, we serve an extraordinary purpose. For 150 years, we have worked tirelessly to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world’s greatest health challenges. Protomer team at Lilly focuses on chemical biology, molecular switches and oral macrocyclic peptide platforms.

This position is for a senior computational biologist‑biochemist with extensive background and knowledge in the field. We are seeking an Advisor/Senior Advisor in Computational Peptide Chemistry to drive peptide discovery programs by providing computational modelling support for the team, and building computational and AI/ML‑based infrastructure at Protomer Team in Eli Lilly. Modeling and computational support will be for multiple projects including support for oral macrocycle efforts.

The successful candidate will work closely with peptide discovery team, structural biologists, assay biologists and medicinal chemists to guide peptide structure‑activity relationship studies from hit identification to lead optimization. The ideal candidate will combine deep technical computational expertise with practical peptide discovery and medicinal chemistry knowledge provided by other members of peptide discovery team to accelerate lead time of peptide discovery programs.

Ideal candidate is a creative computational scientist for the integration of the latest computational and AI/ML‑based approaches into the automated and high‑throughput peptide drug discovery workflows. The ideal candidate is a significant contributor and leading a highly integrated, agile, and collaborative team effort and expected to manage the scientific portfolio, the business supporting the portfolio, and mentoring of junior scientists within the oral macrocycles group al candidate is expected to have demonstrated success in similar roles with proven track record of leading both scientific rationale, planning and execution leading to success in making medicines.

This individual will also be expected to be able to independently lead projects, help shape the team and strategy of the group, contribute significantly to prioritization of the team objectives and interact with and create and nurture the cross‑functional relationships interacting with various therapeutic areas such diabetes and obesity, neuroscience, immunology and oncology.

• Lead biochemist and assay biologist for macrocyclic discovery, contributing insight and developing strategy for assays.
• Work on molecule testing efforts from lead identification to lead optimization and contribute along the way to phase 1b and beyond.
• Provide assay development expertise and support for macrocyclic peptide discovery projects.
• Provide biological insight based on detailed biology of various targets to better focus molecule discovery efforts informed by target biology.
• Develop methodologies, protocols and run SPR and other protein binding assays for characterization of compounds.
• Characterize complete functionality of protein reagents, provide insight and oversight into quality and tracking of protein reagents, and independently lead a small team of biochemists and biologists to support a large molecule discovery group with various targets and assets at different stages of discovery.
• Learn about and enhance the platform technology efforts at Protomer to accelerate assays and biochemical workflows…