Executive Director - Head of Peptide Macrocycles Medicinal Chemistry

Executive Director - Head of Peptide Macrocycles Medicinal Chemistry, leading discovery, optimization, and development of oral macrocyclic drugs.

• formulate and execute strategic direction for macrocycle programs;
• oversee medicinal chemistry efforts using peptide chemistry and library-based screening technologies;
• mentor junior scientists;
• collaborate cross-functionally with ADME, safety, and PK/PD teams;
• drive programs from hit identification to candidate nomination and clinic progression.

• PhD in chemistry, synthetic chemistry, or peptide chemistry;
• extensive experience in oral macrocycle drug discovery, with a proven track record of advancing molecules into clinical testing;
• deep expertise in macrocyclic peptides, library screening technologies (e.g., mRNA display, solution-phase, OBOC), and structure-guided optimization.

• familiarity with computational/AI/machine learning tools in drug development;
• experience in peptide or protein therapeutics clinical success.

• oral macrocyclic peptides
• drug discovery and lead optimization
• candidate progression to clinic
• cross-functional collaboration
• strategic leadership
• team development

onsite Pasadena, CA; some domestic and international travel expected.