Senior Scientist​/Principal Scientist, Quantitative Pharmacology; Contractor

Overview

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogeneic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize cilta-cel. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Senior Scientist/Principal Scientist, Quantitative Pharmacology as part of the Research & Early Development team based in Somerset, NJ
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The position seeks a highly motivated and experienced quantitative pharmacologist to lead modeling and simulation efforts in support of gene and cell therapy products, with a focus on QSP and popPK modeling (prior cell and gene therapy experience preferred).

• Lead QSP and popPK modeling activities across preclinical and clinical development stages.
• Play a pivotal role in shaping clinical pharmacology strategies, supporting regulatory submissions, and driving innovation in model-informed drug development (MIDD).
• Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability.
• Conduct simulations to support dose selection, trial design, and exposure–response analyses.
• Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams.
• Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs).
• Contribute to scientific publications and conference presentations.

• Experience in R&D, preclinical development, clinical, CMC and regulatory contexts.
• MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline.
• 7+ years with MS degree or 3+ years with PhD/Pharm D degree of working experience in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CROs.
• Strong execution ability, independent scientific research capability, logical thinking, and coordination/problem-solving skills.
• Clear written and oral communication skills and good team spirit.
• Demonstrated expertise in QSP and popPK modeling, with proficiency in tools such as NONMEM, R, MATLAB, Monolix, etc.
• Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology and MIDD in clinical trials and drug development.
• Experience applying modeling and simulation to enable rational preclinical and clinical drug development.
• Familiarity with regulatory requirements and guidelines for clinical pharmacology.
• Good project management skills and ability to collaborate with other departments and manage internal and external partners.
• Proven track record of scientific contributions through publications or presentations.
• Positive, trustworthy personality with sound health.

Benefits include medical, dental, and vision insurance, and a 401(k) retirement plan with company match that vests on day one. We offer eight weeks of paid parental leave after three months of employment, and a comprehensive paid time off policy including vacation, personal time, sick time, floating holidays, and eleven company holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance.

We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition…