Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology; Hematology

Legend Biotech is a global biotechnology company headquartered in Somerset, New Jersey, dedicated to developing advanced cell therapies for life‑threatening diseases. We focus on immunotherapy platforms such as chimeric antigen receptor T‑cell, T‑cell receptor (TCR‑T), and natural killer (NK) cell therapies to discover safe and efficacious therapeutics worldwide.

Location:

Somerset, NJ

Role Overview:
We are seeking a highly motivated and innovative Principal Scientist to lead our immunology and immuno‑oncology clinical biomarker projects focused on hematological malignancies. The role involves driving translational understanding, serving as the biology lead on cross‑functional teams, and guiding the mechanism of action and biomarker strategy for novel cell therapies.

• Scientific Leadership:
  Design, execute, and analyze clinical studies to investigate mechanisms of action for IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
• Translational Strategy:
  Bridge discovery and clinical development using primary human samples and clinical datasets to validate targets and understand the immune microenvironment.
• MOA Insight:
  Oversee generation and interpretation of high‑dimensional molecular and cellular data. Leverage advanced single‑cell technologies (e.g., scRNA‑seq) to profile immune cell compartments for patient stratification and biomarker hypotheses.
• Cross‑Functional
  
  Collaboration:
  
  Partner closely with functional teams to enhance understanding of MOA and fundamental immunology.

• Ph.D. in Immunology, Immuno‑Oncology, Cellular Biology, or a closely related discipline; experience leading data‑driven MOA studies.
• 5‑8+ years of post‑doctoral and/or industry experience in biotech or pharma with a proven track record of advancing IO programs.
• Deep understanding of immunology, particularly T‑cell biology, and hematological malignancies, including the blood and bone marrow tumor immune microenvironment.
• Proficiency in analyzing multi‑dimensional data and extracting biological insights.
• Exceptional written and verbal communication skills, able to distill complex data into actionable decisions.

Base Pay Range: $146,410 USD – $192,164 USD (may vary by experience and location). Performance‑based bonus and/or equity is available in eligible roles. Benefits applicable to permanent full‑time employees include medical, dental, and vision insurance; 401(k) with company match; eight weeks of paid parental leave after three months; paid time off (vacation, personal, sick, floating holidays, and 11 company holidays); and voluntary benefits such as flexible spending accounts, health savings accounts, life & AD&D insurance, short‑ and long‑term disability, legal assistance, supplemental insurance plans, commuter benefits, family planning resources, and peer recognition programs.

Contractors are not eligible for benefits.

Legend Biotech provides equal employment opportunities without regard to race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, lactation, and gender identity/expression), sexual orientation, marital status, military service, veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws.

Employment is at‑will and may be terminated at any time with or without cause or notice by the employee or the company.