Senior Director, Controller

At Avalo (ahh-vah'-low), we are 100% focused on developing treatments for immune-mediated inflammatory diseases with large unmet needs that affect millions worldwide. Our strategy is to develop medicines that target the IL-1β pathway, which is a central driver of the inflammatory process.

We share a commitment to teamwork, passion for science, and dedication to patients suffering from acute and chronic inflammatory disorders. Our collective expertise in discovery, development, and regulatory approvals is evidenced in our strong individual track records of advancing multiple therapeutic programs to successful commercialization.

The Sr. Director, Controller will lead Avalo Therapeutics' accounting operations, with primary responsibility for overseeing the company’s monthly, quarterly and annual close process, including leading research and development accounting, general ledger accounting, & accounting, and other corporate accounting functions. Reporting to the VP of Finance, this individual will oversee the Accounting Director and broader GL accounting team while ensuring accurate and timely financial reporting, effective internal controls, and scalable accounting processes that support the Company's growth.

This is a highly collaborative, hands‑on leadership role requiring expertise in biotech R&D accounting, particularly clinical development and CMC accounting, as well as corporate accounting operations in a public company environment. The individual will play a key role in managing close activities, management reporting, audit readiness, SOX compliance and ongoing process improvements while overseeing the day‑to‑day accounting operations that support the Company's continued growth.

• Lead core accounting operations, including close process and general ledger functions, enabling complete, accurate and timely financial reporting.
• Lead and manage the GL accounting team, including oversight of both R&D and G&A accounting functions, through direct management of the Accounting Director and broader accounting team.
• Partner with the Accounting Director and FP&A Team to assess, establish, and document accounting treatment for new, complex, and material R&D, clinical, and manufacturing agreements, while enhancing supporting accounting documentation.
• Review significant accounting estimates, accruals, and other judgmental transactions, including those related to CRO, CMC, clinical trial, and other significant R&D contracts, and drive improvement of supporting workbooks to ensure completeness, accuracy, and audit readiness.
• Lead the G&A accounting function, ensuring accurate accounting, strong controls, and efficient processes related to operating expenses, accruals, cash, prepaids, accounts payable, and other general corporate activities.
• Review journal entries, reconciliations, estimates, and accruals to ensure completeness and accuracy.
• Own and continuously improve the monthly, quarterly, and annual close process.
• Manage the monthly, quarterly, and annual close calendar, driving accountability for key deliverables and ensuring timely completion of close activities while improving efficiency and quality.
• Lead the preparation and evolution of the monthly Close Deck, ensuring financial results are complete and accurate while driving greater transparency, consistency, and decision‑useful reporting for the VP of Finance and CFO.
• Oversee preparation of management reporting schedules supporting executive leadership and Board reporting.
• Lead initiatives to automate and improve accounting processes, controls, and documentation.
• Oversee implementation and optimization of CRO accrual software and other accounting technologies.
• Partner with FP&A to maintain and enhance ERP configuration, department structures, account coding, approval workflows, and system scalability, while assessing future system and process needs to support the Company's growth.
• Partner with the Financial Reporting team to provide timely, accurate, and audit‑ready accounting support, schedules, and analyses necessary for external reporting, SEC filings, and related disclosures.
• Partner closely with…