Medical Director, Clinical Development-Rheumatology

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Discovery & Pre-Clinical/Clinical Development

Clinical Development & Research – MD

Scientific/Technology

Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

The Medical Director provides medical and scientific leadership for late-stage rheumatology clinical development. The role leads assigned studies and contributes to program strategy, with accountability for rigorous trial design, medical oversight, data interpretation, and high-quality clinical and regulatory deliverables.

• Lead the design, execution, analysis, and reporting of Phase 2 and Phase 3 rheumatology trials, aligned with clinical development strategy and regulatory requirements.
• Serve as medical lead for assigned studies, including eligibility guidance, medical monitoring, safety review, protocol deviation assessment, and benefit-risk evaluation.
• Lead cross-functional study teams and drive timely decisions, risk mitigation, and delivery of study milestones.
• Develop and review clinical documents, including study concepts, protocols, investigator brochures, statistical analysis inputs, clinical study reports, and publications.
• Contribute medical content to regulatory submissions, briefing packages, health authority responses, and regulatory interactions.
• Interpret emerging clinical, translational, and competitive evidence and translate it into actionable development recommendations.
• Build effective relationships with investigators, external experts, patient organizations, and development partners.
• Support evaluation of new mechanisms, modalities, and external opportunities relevant to rheumatology and autoimmune disease.
• Mentor clinical team members and contribute to a collaborative, inclusive, and high-accountability culture.

• MD or equivalent medical degree is required.
• Clinical expertise in rheumatology is required, with board certification in rheumatology preferred.
• Typically 3 or more years of relevant clinical development or clinical research experience is preferred, with pharmaceutical or biotechnology industry experience strongly preferred; academic clinical research experience may also be considered.
• Experience leading or materially contributing to interventional clinical trials, including protocol development, medical monitoring, data review, and study reporting, is required.
• Experience with deep depletion approaches or chimeric antigen receptor (CAR) T-cell therapy is desirable.

• Strong clinical judgment and current knowledge of rheumatology, immunology, clinical trial methodology, and Good Clinical Practice.
• Ability to analyze complex data, identify material risks, and…