Associate Scientist

Overview

Posting Title
:
Associate Scientist, Viral Vector Production

Location
:
Spring House, PA

Duration
: 2 years + contract

Pay
: $25-29/hour

Job Description:

The Associate Scientist, Viral Vector Production position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated scientist to execute viral vector production and characterization to enable preclinical studies.

Do you have industry experience with downstream viral vector process development and the ability to thrive in a cross-functional team? Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.

• Support weekly small scale (30 mL) lentiviral vector productions by performing assigned tasks in accordance with established protocols
• Maintain cell lines for vector production and characterization with consistent cell health and strong adherence to safety requirements and aseptic technique
• Perform established molecular assays such as ELISA to meet quality control needs for vector productions
• Support purification of liter-scale LVV productions by learning to assist with downstream processing steps such as basic chromatography and buffer exchange
• Prepare, label, and organize materials, reagents, and samples for scheduled productions; maintain inventory records and ensure material traceability
• Maintain detailed records for vector productions to ensure traceability and data integrity
• Contribute to a collaborative, creative, and rigorous culture of scientific discovery

• BS or MS in Biological Engineering, Chemical Engineering, Virology, Biology, or related field with 0-2 years of related experience is required. Industry experience is preferred.
• Experience with mammalian cell culture and aseptic technique is required
• Experience with lentiviral vector production and/or isolation is strongly preferred
• Experience operating and executing in a core function is preferred
• Desired skills: mammalian cell culture, aseptic technique, transient transfection, protein or viral vector production, chromatography purification
• Strong critical thinking and communication skills are required
• Strong organizational skills, with the ability to independently manage multiple projects in parallel, are required
• Demonstrated ability to work collaboratively in cross-functional teams is required