Principal Scientist, Nonclinical Drug Safety Program Discovery

Overview

Principal Scientist, Nonclinical Drug Safety Program Discovery - Equivalent in level to Scientific Director

We are seeking a Discovery Program Leader (DPL) to represent Nonclinical Drug Safety (NDS) on discovery research teams and in scientific and strategic review meetings focused primarily on immunology and oncology. This position requires exceptional leadership, collaboration, and independence, and a passion to work collaboratively across functions and sites to discover novel medicines that improve the lives of patients.

• Represent NDS on discovery teams and participate in therapeutic area discovery governance committee reviews.
• Promote and facilitate creative thinking from target identification/validation through lead optimization, primarily in the Immunology Therapeutic Area, but also Oncology, Cardiometabolic, Infectious Disease and/or Neuroscience Therapeutic Areas.
• Be a “drug creator” and promoter of innovative thinking by influencing both cross-site disease area aligned groups, as well as functional area disciplines.
• Identify and assess potential risks associated with therapeutic targets or development candidates using available literature, internal data, and external information.
• The individual may also lead early development teams, informing on preclinical studies to support product development.

• PhD in Toxicology, Pharmacology, Pathology, Biology, Biochemistry, Immunology, Pharmaceutical Sciences, Chemistry, or related STEM field, DVM, MD degree or equivalent.
• Minimum 8+ years of demonstrated pharmaceutical industry experience as a non-clinical safety scientist (e.g., Toxicology, Pathology, etc.) and/or as non-clinical safety assessment representative to a cross-functional development and/or discovery teams.
• Demonstrated ability to successfully navigate cross-functional lines and drive team decision making in a matrix organizational structure.
• Highly dedicated, motivated, resilient, and flexible; capable of creative problem solving and delivering on goals and objectives in a timely fashion.
• Excellent team player who can work collaboratively with discovery team members from various functions, other DPLs and scientists responsible for study conduct and portfolio management.
• Excellent interpersonal skills, able to establish good working relationships within networks of employees of all levels.
• Excellent communicator who knows when and how to speak up, and appropriately raise issues to stakeholders and to management.

• Background in immunology is preferred.
• Experience with biopharmaceutical and small molecule pharmaceutical development and/or discovery.
• Experience with regulatory submissions and responses.
• Member of pharmaceutical consortia and/or external scientific or professional organizations.

Adaptability, Combination Products, Drug Development, Drug Discovery Process, Immunology, Immunotherapy, Innovative Thinking, Oncology, Professional Collaboration, Professional Networking, Safety Evaluation, Strategic Thinking, Toxicology

• US and Puerto Rico Residents Only
• Our company is committed to inclusion; accommodations available during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

The salary range for this role is $ - $. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits, including medical, dental, vision, retirement benefits (401(k)), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at

Application information:
You can apply for this role through  or via the Workday Jobs Hub if you are a current employee. The Final date to receive applications is listed on this posting.

Job Posting End Date 07/31/2026

Requisition : R405119