Postdoc fellow – CRISPR screens in hematopoietic stem cells to study replication fitness

University of Pennsylvania:
Postdoctoral Positions:
Perelman School of Medicine Postdoctoral

University of Pennsylvania, Perelman School of Medicine

Jul 31, 2026

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Dr. Tong’s laboratory studies cytokine receptor signaling in replication stress
, DNA repair
, and ubiquitin signaling in hematopoietic stem cells
, bone marrow failure
, and leukemia
. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation, and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in blood development and the prevention of leukemia and ageing. This postdoctoral fellow position will focus on studying the mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function, which leads to bone marrow failure and/or leukemia.

CRISPR screens with our expert collaborators will delineate a new understanding of stem cell fitness upon replication stress and point to potentially druggable pathways for intervention in the treatment of diseases with stem cell dysregulation.

• Cell Stem Cell 28(7):, 2021
• Journal of Clinical Investigation 136(1): e191713, 2026
• Blood 138(22):, 2021
• Blood 133(14): , Apr 2019
• Nature communications 9(1): 3915, Sep 2018
• Genes & developm ent 31(10): , May 2017

You can find more of our recent publications and laboratory information in below website.

https://(Use the "Apply for this Job" box below)./p8146029

Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, and molecular biology, as well as mouse models.

Highly motivated candidates with publication records are encouraged to apply.

Wei Tong, Ph.D - wei.tongnn.edu

Professor and Distinguished Chair in Pediatrics,

Children's Hospital of Philadelphia,

University of Pennsylvania School of Medicine (UPENN),

Co-Director, Hematopoietic Stem Cell program,

Institute for Regenerative Medicine at UPENN

Philadelphia, PA, USA