Principal Scientist, MMoA Biochemist

Principal Scientist, MMoA Biochemist

At GSK, we are focused on developing breakthrough vaccines and medicines for infectious disease. The Vaccines and Infectious Disease Research Unit is leading the way by pioneering a portfolio of novel modalities to tackle the urgent global threat posed by infectious disease. This position offers an excellent opportunity to join our dedicated team, who have end‑to‑end expertise from early discovery through to commercial launch and to drive discovery and mechanism‑of‑action studies for viral, bacterial and fungal therapeutics.

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Our approach to R&D

The Principal Scientist will design and execute cutting‑edge biochemistry research to define mechanisms of action, collaborate with cross‑functional partners (biology, chemistry, pharmacology, clinical, regulatory, IP), and advance projects from early discovery through preclinical development into filing and launch. The role requires keeping pace with scientific advances and integrating new methods to accelerate discovery and support GSK’s mission of improving global health through the development of transformative medicines.

• Lead the strategic design and execution of biochemical experiments, demonstrating thought leadership to define the biochemical mechanism of action of novel therapeutic agents.
• Execute experimental plans by performing internal experiments and/or managing research studies with external partners to drive scientific progress.
• Establish and optimize biochemical and biophysical assays to measure biochemical processes, protein binding and kinetics including data collection, statistical analysis, and interpretation of experimental results.
• Design and generate data packages with structural biology and imaging studies such as cryo-EM in collaboration with cross‑functional teams, generate data packages that enable project decisions.
• Lead communication of scientific findings through written reports, presentations, and publications.
• Author Regulatory Study Reports and manuscripts in peer‑reviewed journals; contribute to IP patent filing and regulatory documents preparation.
• Maintain expert level knowledge of the latest scientific literature and methodologies, contributing to continual innovation and improvement in research practices.
• Ensure compliance with regulatory requirements, ethical guidelines, and GSK standards for data integrity, safety, and quality.

• BS with 8 or more years of relevant experience, MS with 6 or more years of relevant experience or a PhD with 3 or more years of relevant experience with the degree in Biochemistry or another relevant major.
• Three or more years of experience performing a range of biochemical techniques, such as SPR, binding kinetics, DLS, mutagenesis, structural biology and imaging, and other biochemical and biophysical assays.
• Three or more years performing data analysis and interpretation, utilizing statistical methods and scientific software (e.g., Graph Pad Prism, Excel).

• Ability to demonstrate high attention to detail and ensure accuracy of scientific results and documentation in compliance with GSK data integrity standards.
• Excellent communication and teamwork skills, with the ability to work both independently and collaboratively in a team environment.
• Strong problem‑solving and analytical skills.
• Self‑motivated and able to resolve technical challenges and deliver consistent results efficiently in a timely manner.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines.

We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to…