Senior Scientist, Downstream Process​/Antibody-Drug Conjugation

Location: Malvern

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Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Biotherapeutics R&D
Job Category:
Scientific/Technology
All Job Posting Locations:
Malvern, Pennsylvania, United States of America
Job Description:

Employer: Janssen Research & Development, LLC

Job Title: Senior Scientist, Downstream Process/Antibody-Drug Conjugation

Job Code: A011.9366

Job Location: Malvern, PA

Job Type: Full-Time

Job Duties: Support and serve as lead for process development of Antibody-Drug Conjugates (ADCs), Radio-Ligand Therapies (RLTs), Immune-Stimulating Antibody Conjugates (ISACs), siRNA antibody conjugates within the API-Protein group. Lead method and process development activities, process characterization studies, scale-up and tech transfer activities to support large scale GLP and GMP batch manufacturing. Lead the design and execution of development studies to identify and determine appropriate conditions and ranges of critical process parameters for bioconjugation reactions, chromatographic purification, and several types of tangential flow filtration approaches.

Lead the design of experiments, execute planned experiments, optimize process steps to the target process scale at laboratory scale, and participate in the non-GMP and GMP pilot-scale. Record and analyze experimental data, verify data integrity and accuracy, and summarize and report findings. Author technical protocols, reports and regulatory filings. Participate in scoping of laboratory expansion, engage with vendors to source equipment and onboard new instrumentation for ADC lab build activities.

Lead and guide junior scientists to execute various studies for ADC projects, ensure timely completion of deliverables, engage department and global leadership to seek project advancement endorsements, and author technical project development (PD) reports.

Requirements: Employer will accept a Ph.D. degree in Chemistry, Chemical Engineering, Biochemistry or related field and 3 years of experience in the job offered or in a Senior Scientist, Downstream Process/Antibody-Drug Conjugation-related occupation.

This job posting is anticipated to close on 8/3/2026.

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Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Company's long-term incentive program.

Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:

• Vacation
-120 hours per calendar year

• Sick time - 40…