Principal Scientist, Pharmacokinetics

Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)

Location:

West Point, Pennsylvania.

The PDMB function of our Research & Development Division seeks a dynamic, collaborative scientist to serve as a key contributor to multi‑disciplinary drug development and discovery. The Principal Scientist will provide an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk for novel therapeutics. Responsibilities include guiding the design and interpretation of in silico, in vitro, and in vivo analyses, assessing program risks, authoring source reports and regulatory documents, and implementing strategies to mitigate liabilities, ensuring efficient program progression and decision making.

• Collaborate with cross‑functional teams to support the clinical development and discovery of therapeutics across multiple modalities.
• Guide the design and interpretation of in silico, in vitro, and in vivo DMPK analyses to support development of therapeutics with desired profiles.
• Assess program risk including DDI, metabolism, and translation, and provide guidance to clinical development teams.
• Author source reports and regulatory documents in support of filings (IB, IND, WMA).
• Independently evaluate and predict potential program risks, implementing appropriate strategies to address liabilities and aid decision making.
• Provide clear communication with a varied development team and ensure timely risk assessment and clinical plans are in place.

• PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Chemistry, Biomedical Engineering, Biochemistry, or a related life science field.
• Master’s degree with 12+ years of relevant experience or PhD with 8+ years of industry experience in discovery and development of therapeutics across modalities (small molecules, antibodies, drug conjugates).
• Demonstrated ability to support early to late‑stage clinical development programs as a DMPK representative, evaluate and mitigate risks, integrate emerging data, and communicate effectively with cross‑functional teams.
• Experience developing DDI strategy for clinical programs with timely risk assessment and clinical plans.
• Experience authoring documents for IB, IND, WMA filings and responding to regulatory inquiries.
• Lead role on discovery teams advancing therapeutics to clinical development across small molecules, peptides, biologics, and conjugates.
• Strong leadership, interpersonal, communication, problem‑solving, and collaboration skills, with the ability to deliver results on firm deadlines.

• Strong publication track record.
• Experience representing the DMPK function in evaluation of third‑party assets.
• Experience building models and performing analyses using Phoenix, PBPK modeling software (e.g., SimCYP).
• Mentoring or supervising junior staff.

• ADME, Bioanalytical Method Development, Biopharmaceuticals, Biopharmaceutics, Business Interactions, Clinical Development, Clinical Judgment, Cross‑Functional Teamwork, Detail‑Oriented, Drug Development, Drug Interactions, Drug Metabolism, Immunoassays, Innovation, Life Science, Mentoring Staff, Pharmacodynamics, Pharmacokinetics, Pharmacology, PK/PD Modeling.

• Current Employees apply – (information omitted as application process).

Salary Range: $ – $ (based on education, qualifications, experience, geographic location, and business needs). Eligible for annual bonus and long‑term incentive if applicable.

• Medical, dental, vision, and other insurance benefits for employee and family.
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights, EEOC GINA Supplement. We are proud to embrace diversity, inclusivity, and respectful collaboration in our workplace.